Liu Yanjiang, Liu Xi, Shu Yousheng, Yu Yuguo
Research Institute of Intelligent and Complex Systems, Fudan University, Shanghai, 200433, China.
MOE Frontiers Center for Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200433, China.
Neurosci Bull. 2024 Dec;40(12):1960-1974. doi: 10.1007/s12264-024-01277-0. Epub 2024 Sep 4.
In neurons and myocytes, selective ion channels in the plasma membrane play a pivotal role in transducing chemical or sensory stimuli into electrical signals, underpinning neural and cardiac functionality. Recent advancements in biomedical research have increasingly spotlighted the interaction between ion channels and electromagnetic fields, especially terahertz (THz) radiation. This review synthesizes current findings on the impact of THz radiation, known for its deep penetration and non-ionizing properties, on ion channel kinetics and membrane fluid dynamics. It is organized into three parts: the biophysical effects of THz exposure on cells, the specific modulation of ion channels by THz radiation, and the potential pathophysiological consequences of THz exposure. Understanding the biophysical mechanisms underlying these effects could lead to new therapeutic strategies for diseases.
在神经元和心肌细胞中，质膜上的选择性离子通道在将化学或感觉刺激转化为电信号的过程中起着关键作用，是神经和心脏功能的基础。生物医学研究的最新进展越来越多地聚焦于离子通道与电磁场，特别是太赫兹（THz）辐射之间的相互作用。本综述综合了关于以其深度穿透和非电离特性而闻名的太赫兹辐射对离子通道动力学和膜流体动力学影响的当前研究结果。它分为三个部分：太赫兹辐射对细胞的生物物理效应、太赫兹辐射对离子通道的特异性调节，以及太赫兹辐射潜在的病理生理后果。了解这些效应背后的生物物理机制可能会带来针对疾病的新治疗策略。
