依沙克瑞诺会作为二线降压药物被添加到执业医师的降压治疗策略中吗？ - Suppr

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超能文献

Will esaxerenone be added to the antihypertensive treatment strategy of practicing physicians as a second-line antihypertensive drug?

作者信息

Yoshida Tetsuro

机构信息

Department of Cardiovascular Medicine, Onga Nakama Medical Association Onga Hospital, Onga, Japan.

出版信息

Hypertens Res. 2024 Sep;47(9):2574-2576. doi: 10.1038/s41440-024-01802-8. Epub 2024 Jul 11.

DOI:10.1038/s41440-024-01802-8

PMID:39232192

Abstract

摘要

相似文献

Will esaxerenone be added to the antihypertensive treatment strategy of practicing physicians as a second-line antihypertensive drug?依沙克瑞诺会作为二线降压药物被添加到执业医师的降压治疗策略中吗？

Hypertens Res. 2024 Sep;47(9):2574-2576. doi: 10.1038/s41440-024-01802-8. Epub 2024 Jul 11.

Home blood pressure-lowering effect of a non-steroidal mineralocorticoid receptor blocker, esaxerenone, versus trichlormethiazide for uncontrolled hypertension: the EXCITE-HT randomized controlled study.依普利酮降低血压疗效优于三氯噻嗪用于治疗未控制的高血压：EXCITE-HT 随机对照研究

Hypertens Res. 2024 Sep;47(9):2435-2446. doi: 10.1038/s41440-024-01762-z. Epub 2024 Jul 23.

Home blood pressure-lowering effect of esaxerenone versus trichlormethiazide for uncontrolled hypertension: a predefined subanalysis of the EXCITE-HT randomized controlled trial by basal calcium channel blocker versus angiotensin receptor blocker.依普利酮与三氯噻嗪对血压控制不佳的高血压患者的家庭血压降低效果：EXCITE-HT随机对照试验按基础钙通道阻滞剂与血管紧张素受体阻滞剂进行的预定义亚组分析

Hypertens Res. 2025 Feb;48(2):506-518. doi: 10.1038/s41440-024-01887-1. Epub 2024 Oct 12.

Long-term phase 3 study of esaxerenone as mono or combination therapy with other antihypertensive drugs in patients with essential hypertension.依普利酮单药或与其他抗高血压药物联合治疗原发性高血压患者的长期 3 期研究。

Hypertens Res. 2019 Dec;42(12):1932-1941. doi: 10.1038/s41440-019-0314-7. Epub 2019 Sep 25.

Effects of the novel nonsteroidal mineralocorticoid receptor blocker, esaxerenone (CS-3150), on blood pressure and urinary angiotensinogen in low-renin Dahl salt-sensitive hypertensive rats.新型非甾体盐皮质激素受体阻滞剂依斯巴伦诺（CS-3150）对低肾素型 Dahl 盐敏感型高血压大鼠血压和尿血管紧张素原的影响。

Hypertens Res. 2019 Jun;42(6):769-778. doi: 10.1038/s41440-018-0187-1. Epub 2018 Dec 26.

Rationale and Design of a Randomized, Open-Label, Parallel-Group Study of Esaxerenone Versus Angiotensin Receptor Blockers in Older Patients With Uncontrolled Hypertension on Calcium Channel Blocker Monotherapy (ESCORT-HT).依普利酮与血管紧张素受体阻滞剂治疗钙通道阻滞剂单药治疗血压控制不佳的老年患者的随机、开放标签、平行组研究（ESCORT-HT）的原理与设计

J Clin Hypertens (Greenwich). 2025 Jan;27(1):e14947. doi: 10.1111/jch.14947. Epub 2024 Nov 25.

Home blood pressure-lowering effect of esaxerenone vs trichlormethiazide for uncontrolled hypertension: a prespecified subanalysis of the EXCITE-HT randomized controlled study by age subgroup.依普利酮与三氯噻嗪对血压控制不佳的高血压患者的家庭血压降低效果：EXCITE-HT随机对照研究按年龄亚组进行的预先指定亚分析

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Efficacy and safety of esaxerenone (CS-3150) for the treatment of essential hypertension: a phase 2 randomized, placebo-controlled, double-blind study.依普利酮治疗原发性高血压的疗效和安全性：一项 2 期随机、安慰剂对照、双盲研究。

J Hum Hypertens. 2019 Jul;33(7):542-551. doi: 10.1038/s41371-019-0207-x. Epub 2019 May 21.

Synergistic reduction in albuminuria in type 2 diabetic mice by esaxerenone (CS-3150), a novel nonsteroidal selective mineralocorticoid receptor blocker, combined with an angiotensin II receptor blocker.新型非甾体类选择性盐皮质激素受体阻滞剂依斯巴群（CS-3150）与血管紧张素 II 受体阻滞剂联合应用可协同降低 2 型糖尿病小鼠的蛋白尿。

Hypertens Res. 2020 Nov;43(11):1204-1213. doi: 10.1038/s41440-020-0495-0. Epub 2020 Jul 2.

Double-Blind Randomized Phase 3 Study Comparing Esaxerenone (CS-3150) and Eplerenone in Patients With Essential Hypertension (ESAX-HTN Study).Esaxerenone（CS-3150）与依普利酮治疗原发性高血压的双盲随机 3 期研究（ESAX-HTN 研究）。

Hypertension. 2020 Jan;75(1):51-58. doi: 10.1161/HYPERTENSIONAHA.119.13569. Epub 2019 Dec 2.

本文引用的文献

Efficacy and Safety of Esaxerenone in Hypertensive Patients with Left Ventricular Hypertrophy (ESES-LVH) Study: A Multicenter, Open-Label, Prospective, Interventional Study.依普利酮治疗高血压伴左心室肥厚（ESES-LVH）患者的疗效和安全性研究：一项多中心、开放标签、前瞻性、干预性研究。

Adv Ther. 2024 Mar;41(3):1284-1303. doi: 10.1007/s12325-024-02780-6. Epub 2024 Feb 4.

Exploratory study on the relationship between urinary sodium/potassium ratio, salt intake, and the antihypertensive effect of esaxerenone: the ENaK Study.依普利酮钠钾比值、盐摄入量与降压疗效关系的探索性研究：ENaK 研究。

Hypertens Res. 2024 Apr;47(4):835-848. doi: 10.1038/s41440-023-01519-0. Epub 2024 Jan 11.

Nighttime home blood pressure lowering effect of esaxerenone in patients with uncontrolled nocturnal hypertension: the EARLY-NH study.依普利酮对夜间血压控制不佳的患者的夜间家庭血压降低作用：EARLY-NH 研究。

Hypertens Res. 2023 Jul;46(7):1782-1794. doi: 10.1038/s41440-023-01292-0. Epub 2023 May 12.

Sodium-Glucose Cotransporter 2 Inhibitors and Risk of Hyperkalemia in People With Type 2 Diabetes: A Meta-Analysis of Individual Participant Data From Randomized, Controlled Trials.钠-葡萄糖协同转运蛋白2抑制剂与2型糖尿病患者高钾血症风险：来自随机对照试验的个体参与者数据的荟萃分析

Circulation. 2022 May 10;145(19):1460-1470. doi: 10.1161/CIRCULATIONAHA.121.057736. Epub 2022 Apr 8.

Nighttime Blood Pressure Phenotype and Cardiovascular Prognosis: Practitioner-Based Nationwide JAMP Study.夜间血压表型与心血管预后：基于实践的日本高血压与代谢异常及其对策纵向研究。

Circulation. 2020 Nov 10;142(19):1810-1820. doi: 10.1161/CIRCULATIONAHA.120.049730. Epub 2020 Nov 2.

Hypertension. 2020 Jan;75(1):51-58. doi: 10.1161/HYPERTENSIONAHA.119.13569. Epub 2019 Dec 2.

The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019).日本高血压学会高血压管理指南（JSH 2019）。

Hypertens Res. 2019 Sep;42(9):1235-1481. doi: 10.1038/s41440-019-0284-9.

Resistant hypertension: a review of diagnosis and management.耐药性高血压：诊断与管理综述。

JAMA. 2014 Jun 4;311(21):2216-24. doi: 10.1001/jama.2014.5180.

Mineralocorticoid receptor-associated hypertension and its organ damage: clinical relevance for resistant hypertension.醛固酮受体相关性高血压及其器官损害：与难治性高血压的临床相关性。

Am J Hypertens. 2012 May;25(5):514-23. doi: 10.1038/ajh.2011.245. Epub 2012 Jan 19.

Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease.Rac1 GTP酶对盐皮质激素受体功能的调节：在蛋白尿性肾病中的意义

Nat Med. 2008 Dec;14(12):1370-6. doi: 10.1038/nm.1879. Epub 2008 Nov 23.

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