Department of Neurology, School of Medicine, Hazrat Rasool-E Akram, General Hospital, Iran University of Medical Sciences, Tehran, Iran.
Department of Molecular Genetics, Faculty of Biological Science, Tarbiat Modares University, Tehran, Iran.
Pathol Res Pract. 2024 Oct;262:155576. doi: 10.1016/j.prp.2024.155576. Epub 2024 Aug 30.
Cancer-associated fibroblasts are the most important cellular component of the tumor microenvironment, controlling cancer progression and therapeutic response. These cells in the tumor microenvironment regulate tumor progression and development as oncogenic or tumor suppressor agents. However, the mechanisms by which CAFs communicate with cancer cells remain to investigate. Here, we review evidence that extracellular vesicles, particularly exosomes, serve as vehicles for the intercellular transfer of bioactive cargos, notably microRNAs and long non-coding RNAs, from CAFs to cancer cells. We try to highlight molecular pathways of non-coding RNAs and the interaction among these molecules. Together, these findings elucidate a critical exosome-based communication axis by which CAFs create mostly a supportive pro-tumorigenic microenvironment and highlight therapeutic opportunities for disrupting this intercellular crosstalk.
癌症相关成纤维细胞是肿瘤微环境中最重要的细胞成分，控制着肿瘤的进展和治疗反应。这些肿瘤微环境中的细胞作为致癌或抑癌因子调节肿瘤的进展和发展。然而，CAF 与癌细胞之间的通讯机制仍有待研究。在这里，我们综述了证据表明，细胞外囊泡，特别是外泌体，作为生物活性货物（特别是 microRNAs 和长非编码 RNA）从 CAF 到癌细胞的细胞间转移的载体。我们试图强调非编码 RNA 的分子途径以及这些分子之间的相互作用。这些发现共同阐明了基于外泌体的关键通讯轴，CAF 通过该通讯轴构建主要是支持肿瘤发生的微环境，并强调了打破这种细胞间串扰的治疗机会。
