Division of Nephrology and Hypertension, Mayo Clinic Arizona, Phoenix, AZ.
Division of Infectious Diseases, Mayo Clinic Arizona, Phoenix, AZ.
Adv Kidney Dis Health. 2024 Sep;31(5):458-465. doi: 10.1053/j.akdh.2024.03.004.
The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 has led to the death of about 7 million people worldwide. When infected, older individuals and those with diabetes, hypertension, cardiovascular disease, and compromised immune system are at higher risk for unfavorable outcomes. These comorbidities are prevalent in kidney transplant candidates and recipients making them inherently vulnerable to severe acute respiratory syndrome coronavirus 2 infection, hence, the significant burden the pandemic has exerted on kidney transplant programs. With the swift discovery and wide-scale availability of vaccines and therapeutics against severe acute respiratory syndrome coronavirus 2, the pandemic is currently behind us allowing transplant programs to relieve their restrictions and resume normal pre-COVID-19 operations. In the aftermath of the pandemic, we discuss the implications for immunosuppression and vaccination, COVID-19-induced kidney injury phenotypes and long COVID-19 symptoms. We also discuss some of the operational aspects the pandemic brought about - mainly the utilization of telemedicine - that are now here to stay.
2019 年冠状病毒病（COVID-19）大流行是由严重急性呼吸系统综合征冠状病毒 2 引起的，导致全球约 700 万人死亡。感染时，老年人以及患有糖尿病、高血压、心血管疾病和免疫系统受损的人患不良结局的风险更高。这些合并症在肾移植候选人和受者中很常见，使他们容易受到严重急性呼吸系统综合征冠状病毒 2 的感染，因此，大流行对肾移植项目造成了巨大负担。随着针对严重急性呼吸系统综合征冠状病毒 2 的疫苗和治疗方法的迅速发现和广泛应用，大流行目前已经过去，使移植项目能够解除限制并恢复 COVID-19 之前的正常运作。在大流行之后，我们讨论了免疫抑制和疫苗接种、COVID-19 引起的肾损伤表型和长 COVID-19 症状的影响。我们还讨论了大流行带来的一些运营方面的问题——主要是远程医疗的利用——这些问题现在已经存在且将继续存在。
