Department of Internal Medicine and Nephrology, Herz-Jesu-Krankenhaus Münster-Hiltrup, Münster-Hiltrup, Germany.
Institute of Pathology, Nephropathology Section, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
BMC Nephrol. 2024 Sep 4;25(1):291. doi: 10.1186/s12882-024-03694-9.
Membranoproliferative glomerulonephritis is a rare entity which can be a result from autoimmune diseases, caused by various medications and infections.
We herein present the case of a 62-year-old male patient who presented with fatigue and was found to have severe anemia, impaired renal function, and nephrotic syndrome. A renal biopsy revealed membranoproliferative glomerulonephritis (MPGN) of the immune complex type with activation of the classical complement pathway. Further investigations led to the diagnosis of a chronic Coxiella burnetii-infection (Q fever), likely acquired during cycling trips in a region known for intensive sheep farming. Additionally, the patient was found to have a post endocarditic destructive bicuspid aortic valve caused by this pathogen. Treatment with hydroxychloroquine and doxycycline was administered for a duration of 24 months. The aortic valve was replaced successfully and the patient recovered completely.
Early detection and targeted treatment of this life-threatening disease is crucial for complete recovery of the patient.
膜增生性肾小球肾炎是一种罕见的疾病，可由自身免疫性疾病、各种药物和感染引起。
我们在此介绍一例 62 岁男性患者，其表现为乏力，并发现严重贫血、肾功能受损和肾病综合征。肾活检显示免疫复合物型膜增生性肾小球肾炎（MPGN），经典补体途径被激活。进一步的调查导致诊断为慢性柯克斯体感染（Q 热），可能是在一个以密集绵羊养殖而闻名的地区骑自行车旅行时感染的。此外，该患者还被发现患有由该病原体引起的心内膜炎后破坏性二叶主动脉瓣。给予羟氯喹和多西环素治疗 24 个月。成功更换了主动脉瓣，患者完全康复。
早期发现和针对这种危及生命的疾病的治疗对患者的完全康复至关重要。
