Key Laboratory of Environmental Pollution and Integrative Omics, Education Department of Guangxi Zhuang Autonomous Region, Guilin Medical University, Guilin, China; Lingui Clinical College of Guilin Medical University, Guilin, China.
Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region of China.
Int J Biol Macromol. 2024 Nov;279(Pt 3):135268. doi: 10.1016/j.ijbiomac.2024.135268. Epub 2024 Sep 2.
Fucoidan is a sulfate-containing polysaccharide derived from the cell walls of brown algae and marine invertebrates. Fucoidan is widely used for the treatment of various diseases owing to its various biological activities. Dermatitis is an inflammatory reaction that affects the skin. The primary clinical manifestations include atopic dermatitis (AD or eczema) and various subtypes of contact dermatitis. The treatment of dermatitis primarily improves symptoms and reduces inflammation. However, owing to individual variations, some patients have a poor prognosis or symptom recurrence after conventional treatment. Owing to the excellent anti-allergic and anti-inflammatory activities of the low cost nature compound fucoidan, its therapeutic effect in inflammatory diseases has recently attracted the attention of researchers. This article summarizes and analyzes the advantages and pharmacological mechanisms of fucoidan against dermatitis to provide a reference for the selection of drugs for the treatment of dermatitis.
岩藻聚糖是一种从褐藻和海洋无脊椎动物细胞壁中提取的含硫酸盐多糖。由于其多种生物活性，岩藻聚糖被广泛用于治疗各种疾病。皮炎是一种影响皮肤的炎症反应。主要的临床症状包括特应性皮炎（AD 或湿疹）和各种接触性皮炎亚型。皮炎的治疗主要是改善症状和减轻炎症。然而，由于个体差异，一些患者在常规治疗后预后较差或症状复发。由于低成本天然化合物岩藻聚糖具有出色的抗过敏和抗炎活性，其在炎症性疾病中的治疗效果最近引起了研究人员的关注。本文总结和分析了岩藻聚糖治疗皮炎的优势和药理学机制，为治疗皮炎的药物选择提供参考。
