Department of Urology, Peking University People's Hospital, Beijing 100044, China; The Institute of Applied Lithotripsy Technology, Peking University, Beijing 100044, China.
Naval Aviation University, No.188, Erma Road, Zhifu District, Yantai, Shandong Province 264008, China.
J Affect Disord. 2024 Dec 15;367:210-218. doi: 10.1016/j.jad.2024.08.205. Epub 2024 Sep 3.
The prevalence of Lower Urinary Tract Symptoms suggestive of Benign Prostatic Hyperplasia (LUTS/BPH) is notably high and potentially elevates the likelihood of depressive symptoms. This study was designed to employ both cross-sectional and longitudinal methodologies to explore the correlation between LUTS/BPH and depressive symptoms among middle-aged and elderly men in China.
This investigation utilized data from the China Health and Retirement Longitudinal Study (CHARLS), with the initial dataset from 2015 serving as the baseline and subsequent data from 2018 and 2020 facilitating longitudinal analysis. The study encompassed a baseline cohort of 5156 men aged 45 years and above, and an expansive longitudinal analytical sample of 23,530 participants spanning from 2015 to 2020. The assessment of depressive symptoms was conducted using the 10-item Center for Epidemiological Studies Depressive Symptoms Scale (CESD-10). To investigate the factors associated with LUTS/BPH, the relationship between LUTS/BPH and depressive symptoms, and to evaluate the incidence rate of depressive symptoms onset based on LUTS/BPH status, multivariate logistic analyses and logistic regression models were employed.
Our results reveal a markedly higher incidence of depressive symptoms among individuals with LUTS/BPH, at 30.16 %, compared to 22.94 % in those without LUTS/BPH. This pattern was consistent in both mild and moderate depressive symptoms categories. However, the prevalence of severe depressive symptoms did not exhibit a significant disparity between the two groups. Longitudinal analysis spanning from 2015 through 2018 and 2020 further corroborated these observations. Individuals with LUTS/BPH showed a substantially higher incidence of depressive symptoms across all severity levels compared to those without LUTS/BPH. Specifically, the presence of LUTS/BPH was linked to a 53 % heightened risk of mild depressive symptoms, a 45 % increase in moderate depressive symptoms, and an alarming 229 % surge in severe depressive symptoms risk between 2015 and 2018. Additionally, from 2015 to 2020, there was a 30 % increased risk for mild depressive symptoms, a 41 % rise for moderate depressive symptoms, and a 106 % escalation in the risk of severe depressive symptoms among those with LUTS/BPH.
In middle-aged and older Chinese adults, LUTS/BPH were correlated with an elevated risk of depressive symptoms.
下尿路症状（LUTS）提示良性前列腺增生（BPH）的患病率显著较高，可能会增加抑郁症状的可能性。本研究旨在采用横断面和纵向方法探讨中国中老年男性 LUTS/BPH 与抑郁症状之间的相关性。
本研究利用中国健康与退休纵向研究（CHARLS）的数据，以 2015 年的初始数据集作为基线，随后 2018 年和 2020 年的数据进行纵向分析。研究包括 5156 名年龄在 45 岁及以上的基线队列和 2015 年至 2020 年期间的 23530 名参与者的广泛纵向分析样本。使用 10 项中心流行病学研究抑郁症状量表（CESD-10）评估抑郁症状。为了探讨与 LUTS/BPH 相关的因素、LUTS/BPH 与抑郁症状之间的关系，以及根据 LUTS/BPH 状况评估抑郁症状发病的发生率，采用多变量逻辑分析和逻辑回归模型进行分析。
我们的结果显示，患有 LUTS/BPH 的个体中抑郁症状的发生率明显较高，为 30.16%，而无 LUTS/BPH 的个体中为 22.94%。在轻度和中度抑郁症状类别中均存在这种模式。然而，两组之间重度抑郁症状的患病率没有显著差异。从 2015 年到 2018 年和 2020 年的纵向分析进一步证实了这一观察结果。与无 LUTS/BPH 的个体相比，患有 LUTS/BPH 的个体在所有严重程度水平上的抑郁症状发生率均显著更高。具体而言，LUTS/BPH 的存在使轻度抑郁症状的风险增加 53%，中度抑郁症状的风险增加 45%，重度抑郁症状的风险增加 229%，这一风险从 2015 年到 2018 年期间显著增加。此外，从 2015 年到 2020 年，患有 LUTS/BPH 的个体轻度抑郁症状的风险增加 30%，中度抑郁症状的风险增加 41%，重度抑郁症状的风险增加 106%。
在中国中老年成年人中，LUTS/BPH 与抑郁症状风险增加相关。
