Department of Urology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan.
BJU Int. 2012 Oct;110(7):1023-9. doi: 10.1111/j.1464-410X.2011.10866.x. Epub 2012 Jan 11.
Study Type - Symptom prevalence (cohort) Level of Evidence 2b. What's known on the subject? and What does the study add? There have been few longitudinal community-based studies on LUTS suggestive of BPH. It is important to determine the natural history of LUTS suggestive of BPH among men in various countries because it is known that there are differences according to race. Although we previously reported a cross-sectional community-based survey on LUTS suggestive of BPH in Japanese men, no longitudinal data were available. The present study provides 15-year longitudinal data on LUTS suggestive of BPH and related variables in Japanese men.
To report the natural history of benign prostatic hyperplasia (BPH)/lower urinary tract symptoms (LUTS) in Japanese men.
From 1992 to 1993, we conducted a cross-sectional community-based study on LUTS suggestive of BPH in Japanese men aged 40-79 years. • After 15 fifteen years, a follow-up study was conducted to determine their longitudinal changes of LUTS. • Of the 319 participants taking part in the initial study, 135 participated again in the follow-up study. • We investigated International Prostate Symptom Score (IPSS), quality of life index and bother score using a questionnaire, and measured prostate volume (PV), prostate-specific antigen (PSA) level and peak urinary flow rate (Q(max) ) using a method that we have employed previously.
The change in the total IPSS during 15 years was significant (P= 0.001) and its mean (sd) annual change was 0.11 (0.40). • Although there was little change in the bother score, a significant correlation was observed between changes in the IPSS and bother score (r= 0.528, P < 0.001). • For the individual IPSS and bother scores, only changes in urgency, weak stream and nocturia were significant. • The changes in PV, PSA level and Q(max) were significant. • The change in the total IPSS did not correlate with the changes in these variables.
In a 15-year-longitudinal community-based study for Japanese men, we have shown that the IPSS and quality of life index deteriorated, PV and PSA level increased, and Q(max) decreased.
研究类型 - 症状流行率（队列）证据水平 2b。 关于这个主题已经知道了什么？ 这项研究有什么新发现？ 关于提示前列腺增生症（BPH）的下尿路症状（LUTS）的纵向社区研究很少。 确定不同国家男性提示 BPH 的 LUTS 的自然病史很重要，因为已知根据种族存在差异。 虽然我们之前报告了一项关于日本男性提示 BPH 的 LUTS 的横断面社区研究，但没有可用的纵向数据。 本研究提供了日本男性提示 BPH 的 LUTS 及相关变量的 15 年纵向数据。
报告日本男性良性前列腺增生症（BPH）/下尿路症状（LUTS）的自然病史。
1992 年至 1993 年，我们对 40-79 岁的日本男性进行了一项关于提示 BPH 的 LUTS 的横断面社区研究。 • 15 年后，进行了一项随访研究，以确定他们的 LUTS 纵向变化。 • 在最初研究中参加的 319 名参与者中，有 135 名再次参加了随访研究。 • 我们使用问卷调查了国际前列腺症状评分（IPSS）、生活质量指数和困扰评分，并使用我们之前使用的方法测量了前列腺体积（PV）、前列腺特异性抗原（PSA）水平和最大尿流率（Q(max)）。
15 年内总 IPSS 的变化具有统计学意义（P=0.001），其平均（标准差）年变化为 0.11（0.40）。 • 尽管困扰评分变化不大，但 IPSS 和困扰评分之间存在显著相关性（r=0.528，P<0.001）。 • 对于个体的 IPSS 和困扰评分，只有尿急、弱流和夜尿症的变化具有统计学意义。 • PV、PSA 水平和 Q(max) 的变化具有统计学意义。 • 总 IPSS 的变化与这些变量的变化无关。
在一项针对日本男性的 15 年纵向社区研究中，我们表明 IPSS 和生活质量指数恶化，PV 和 PSA 水平升高，Q(max) 降低。
