Dash Om Prakash, Garg Divya, Volla Chandra M R
Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai-400076, India.
Chem Commun (Camb). 2024 Sep 20;60(76):10576-10579. doi: 10.1039/d4cc03797a.
Herein, we report Rh(III) catalyzed aldehydic or aryl C-H alkylation C-C bond activation of cyclopropanols, facilitating the synthesis of β-functionalized ketones. The protocol employs cyclopropanol as the alkylating agent with 2-aminobenzaldehyde or aniline derivatives to access a variety of unsymmetrical 1,4-diketones or β-aryl ketones, respectively. The practicality of these transformations is showcased through the modification of natural products, gram-scale synthesis, broad substrate scope and postfunctionalizations.
在此，我们报道了铑（III）催化的环丙醇的醛基或芳基C-H烷基化以及C-C键活化反应，该反应有助于β-官能化酮的合成。该方案使用环丙醇作为烷基化试剂，分别与2-氨基苯甲醛或苯胺衍生物反应，以得到各种不对称的1,4-二酮或β-芳基酮。这些转化反应的实用性通过天然产物的修饰、克级规模合成、广泛的底物范围和后期官能化得以展现。
