人体急性氯化铵酸中毒期间的高钾血症。

Hyperkalemia during acute ammonium chloride acidosis in man.

作者信息

Bushinsky D A, Coe F L

出版信息

Nephron. 1985;40(1):38-40. doi: 10.1159/000183424.

Abstract

The relationship between acid base parameters and serum potassium concentration was studied in controls and in patients during acute ammonium chloride-induced metabolic acidosis. Serum potassium was best correlated with serum bicarbonate during control (r = -0.323; p less than 0.01) and acidosis (r = -0.437; p less than 0.001). The slopes and intercepts were similar in both instances and the combined correlation was highly significant (r = -0.493; p less than 0.001). Examination of the 95% joint confidence region revealed that during acidosis serum potassium was rarely above 5.0 mEq/l when serum bicarbonate was greater than 16 mEq/l. It is probably not sound clinical practice to ascribe hyperkalemia to acute mild metabolic acidosis.

摘要

在对照组以及急性氯化铵诱发的代谢性酸中毒患者中，研究了酸碱参数与血清钾浓度之间的关系。在对照期间（r = -0.323；p < 0.01）以及酸中毒期间（r = -0.437；p < 0.001），血清钾与血清碳酸氢盐的相关性最佳。两种情况下的斜率和截距相似，联合相关性高度显著（r = -0.493；p < 0.001）。对95%联合置信区间的检查显示，在酸中毒期间，当血清碳酸氢盐大于16 mEq/l时，血清钾很少高于5.0 mEq/l。将高钾血症归因于急性轻度代谢性酸中毒可能并非合理的临床做法。