慢性肾病中的氯化铵中毒
Ammonium chloride poisoning in chronic renal disease.
作者信息
Levene D L, Knight A
出版信息
Can Med Assoc J. 1974 Aug 17;111(4):335 passim.
A 58-year-old woman with a long history of renal stone disease and urinary tract infection presented to the emergency room with exhaustion and air hunger. Laboratory data confirmed profound metabolic acidosis. Unduly large quantities of bicarbonate and potassium were required for correction of the deficits. She had been taking 6 g daily of ammonium chloride as a urine-acidifying agent for a period of six months in addition to agents directed against urinary tract infection. The combination of impaired renal function and effective hydrogen ion loading resulted in profound systemic acidosis. The metabolic derangements associated with the administration of ammonium chloride and its use as a therapeutic agent are discussed.
一名有肾结石病史和尿路感染史的58岁女性因疲惫和气促就诊于急诊室。实验室检查证实存在严重代谢性酸中毒。纠正酸碱和钾离子缺乏需要大量的碳酸氢盐和钾。除了使用治疗尿路感染的药物外，她还服用了六个月的氯化铵，每日剂量为6克，作为尿液酸化剂。肾功能受损与有效的氢离子负荷相结合导致了严重的全身酸中毒。本文讨论了与氯化铵给药及其作为治疗药物使用相关的代谢紊乱。
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