Nalugo Margaret, Schulte Linda J, Masood Muhammad F, Zayed Mohamed A
Section of Vascular Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO, United States.
Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO, United States.
Front Cardiovasc Med. 2021 Feb 2;8:636843. doi: 10.3389/fcvm.2021.636843. eCollection 2021.
The coronavirus disease-2019 (COVID-19) pandemic has rapidly spread across the world. The disease is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which first appeared in Wuhan, China in December, 2019. Ever increasing data is continuing to emerge about the impact of COVID-19 on cardiovascular tissue and other organ system. Clinical features associated with COVID-19 suggest that endothelial cell dysfunction and microvascular thrombosis are to a large extent contributing to resultant multi-organ complications. This review is aimed at highlighting the critical aspects associated with COVID-19 and its presumed microvascular angiopathic consequences on the cardiovascular system leading to multi-organ dysfunction.
2019年冠状病毒病(COVID-19)大流行已在全球迅速蔓延。该疾病由严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引起,该病毒于2019年12月首次在中国武汉出现。关于COVID-19对心血管组织和其他器官系统影响的数据不断涌现。与COVID-19相关的临床特征表明,内皮细胞功能障碍和微血管血栓形成在很大程度上导致了多器官并发症。本综述旨在强调与COVID-19相关的关键方面及其对心血管系统可能产生的微血管病变后果,这些后果会导致多器官功能障碍。