Department of Medical Imaging Center, Northwest Women's and Children's Hospital, Xi'an, China.
Department of Cardiovascular Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.
Front Public Health. 2024 Aug 21;12:1462548. doi: 10.3389/fpubh.2024.1462548. eCollection 2024.
Previous studies indicated that exposure to ambient fine particulate matter (PM) could increase the risk of metabolic syndrome (MetS). However, the specific impact of PM chemical components remains uncertain.
A national cross-sectional study of 12,846 Chinese middle-aged and older adults was conducted. Satellite-based spatiotemporal models were employed to determine the 3-year average PM components exposure, including sulfates (SO ), nitrates (NO ), ammonia (NH ), black carbon (BC), and organic matter (OM). Generalized linear models were used to investigate the associations of PM components with MetS and the components of MetS, and restricted cubic splines curves were used to establish the exposure-response relationships between PM components with MetS, as well as the components of MetS.
MetS risk increased by 35.1, 33.5, 33.6, 31.2, 32.4, and 31.4% for every inter-quartile range rise in PM, SO , NO , NH , OM and BC, respectively. For MetS components, PM chemical components were associated with evaluated risks of central obesity, high blood pressure (high-BP), high fasting glucose (high-FBG), and low high-density lipoprotein cholesterol (low-HDL).
This study indicated that exposure to PM components is related to increased risk of MetS and its components, including central obesity, high-BP, high-FBG, and low-HDL. Moreover, we found that the adverse effect of PM chemical components on MetS was more sensitive to people who were single, divorced, or widowed than married people.
先前的研究表明，暴露于环境细颗粒物（PM）会增加代谢综合征（MetS）的风险。然而，PM 化学组分的具体影响仍不确定。
对 12846 名中国中老年成年人进行了一项全国性的横断面研究。采用基于卫星的时空模型来确定 3 年平均 PM 组分暴露情况，包括硫酸盐（SO ）、硝酸盐（NO ）、氨（NH ）、黑碳（BC）和有机物（OM）。广义线性模型用于研究 PM 组分与 MetS 及 MetS 各组分之间的关联，限制立方样条曲线用于建立 PM 组分与 MetS 以及 MetS 各组分之间的暴露-反应关系。
PM 每增加一个四分位间距，MetS 风险分别增加 35.1%、33.5%、33.6%、31.2%、32.4%和 31.4%。对于 MetS 各组分，PM 化学组分与中心性肥胖、高血压（高-BP）、高空腹血糖（高-FBG）和低高密度脂蛋白胆固醇（低-HDL）的评估风险相关。
本研究表明，暴露于 PM 组分与 MetS 及其各组分（包括中心性肥胖、高-BP、高-FBG 和低-HDL）的风险增加有关。此外，我们发现 PM 化学组分对 MetS 的不良影响对于单身、离婚或丧偶者比对已婚者更为敏感。
