Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, China.
Intensive Care Unit, Northern Jiangsu People's Hospital, Yangzhou, China.
Front Immunol. 2024 Aug 21;15:1461051. doi: 10.3389/fimmu.2024.1461051. eCollection 2024.
As a grave and highly lethal clinical challenge, sepsis, along with its consequent multiorgan dysfunction, affects millions of people worldwide. Sepsis is a complex syndrome caused by a dysregulated host response to infection, leading to fatal organ dysfunction. An increasing body of evidence suggests that the pathogenesis of sepsis is both intricate and rapid and involves various cellular responses and signal transductions mediated by post-translational modifications (PTMs). Hence, a comprehensive understanding of the mechanisms and functions of PTMs within regulatory networks is imperative for understanding the pathological processes, diagnosis, progression, and treatment of sepsis. In this review, we provide an exhaustive and comprehensive summary of the relationship between PTMs and sepsis-induced organ dysfunction. Furthermore, we explored the potential applications of PTMs in the treatment of sepsis, offering a forward-looking perspective on the understanding of infectious diseases.
作为一种严重且极具致命性的临床挑战，脓毒症及其导致的多器官功能障碍影响着全球数百万人。脓毒症是一种由宿主对感染的失调反应引起的复杂综合征，可导致致命的器官功能障碍。越来越多的证据表明，脓毒症的发病机制既复杂又迅速，涉及各种细胞反应和信号转导，这些反应和信号转导是由翻译后修饰（PTMs）介导的。因此，全面了解调节网络中 PTMs 的机制和功能对于理解脓毒症的病理过程、诊断、进展和治疗至关重要。在这篇综述中，我们详细全面地总结了 PTMs 与脓毒症引起的器官功能障碍之间的关系。此外，我们探讨了 PTMs 在脓毒症治疗中的潜在应用，为理解传染病提供了前瞻性视角。
