Song Lin, Ma JingYi, Jiang Wei, Liu Ke, Wang Jing, Lin Hua, Yu Jiangquan, Zheng Ruiqiang
Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, China.
Intensive Care Unit, Northern Jiangsu People's Hospital, Yangzhou, China.
Front Med (Lausanne). 2025 Jul 22;12:1606786. doi: 10.3389/fmed.2025.1606786. eCollection 2025.
Sepsis is a clinical syndrome characterized by high morbidity and mortality rates, posing a severe threat to human health. Its pathophysiology is complex, involving multiple physiological and pathological processes. Protein post-translational modification (PTM) play a pivotal role in the pathophysiology of sepsis by regulating inflammation, immune responses, and organ dysfunction. In recent years, there has been a growing focus on the association between sepsis and PTM; however, a comprehensive and systematic analysis of the current research status and development trends in this field is still lacking.
This study analyzed literature from the Web of Science Core Collection published between 2005 and 2024. CiteSpace, VOSviewer, and Excel facilitated the bibliometric analysis, visualizing publication trends, contributions across countries/regions and institutions, journal distributions, author collaboration networks, and keyword clusters.
A total of 1705 articles were included, originating from 58 countries/regions. The annual publication volume showed exponential growth ( = 0.9662), with China leading the way (48.68%), followed by the United States (29.27%). Shanghai Jiao Tong University emerged as a high-yield institution ( = 51), while the University of Pittsburgh demonstrated the highest citation impact (with an average of 109.87 citations per article). Prominent journals featuring these articles include Shock ( = 77) and the Journal of Immunology (with an average citation of 65.75 times per article). Research hotspots were centered around phosphorylation, ubiquitination, and methylation, with emerging trends such as sepsis-associated acute kidney injury (SA-AKI), autophagy, and mitochondrial dysfunction.
Research on the sepsis-related PTM is flourishing. This study systematically reveals the research dynamics and core trends in this field.
脓毒症是一种临床综合征，具有高发病率和死亡率，对人类健康构成严重威胁。其病理生理学复杂，涉及多个生理和病理过程。蛋白质翻译后修饰（PTM）通过调节炎症、免疫反应和器官功能障碍在脓毒症的病理生理学中起关键作用。近年来，脓毒症与PTM之间的关联受到越来越多的关注；然而，该领域目前的研究现状和发展趋势仍缺乏全面系统的分析。
本研究分析了2005年至2024年期间发表在科学网核心合集中的文献。CiteSpace、VOSviewer和Excel辅助进行文献计量分析，直观呈现出版趋势、各国/地区和机构的贡献、期刊分布、作者合作网络以及关键词聚类。
共纳入1705篇文章，来自58个国家/地区。年发表量呈指数增长（r = 0.9662），中国领先（48.68%），其次是美国（29.27%）。上海交通大学是高产机构（r = 51），而匹兹堡大学的被引影响力最高（每篇文章平均被引109.87次）。发表这些文章的著名期刊包括《休克》（r = 77）和《免疫学杂志》（每篇文章平均被引65.75次）。研究热点集中在磷酸化、泛素化和甲基化，还有脓毒症相关急性肾损伤（SA-AKI）、自噬和线粒体功能障碍等新兴趋势。
脓毒症相关PTM的研究蓬勃发展。本研究系统揭示了该领域的研究动态和核心趋势。
