Suppr超能文献

音高修正出现在自然言语中,而在阿尔茨海默病患者中则是异常的。

Pitch corrections occur in natural speech and are abnormal in patients with Alzheimer's disease.

作者信息

Subrahmanya Anantajit, Ranasinghe Kamalini G, Kothare Hardik, Raharjo Inez, Kim Kwang S, Houde John F, Nagarajan Srikantan S

机构信息

Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States.

Department of Neurology, University of California, San Francisco, San Francisco, CA, United States.

出版信息

Front Hum Neurosci. 2024 Aug 21;18:1424920. doi: 10.3389/fnhum.2024.1424920. eCollection 2024.

Abstract

Past studies have explored formant centering, a corrective behavior of convergence over the duration of an utterance toward the formants of a putative target vowel. In this study, we establish the existence of a similar centering phenomenon for pitch in healthy elderly controls and examine how such corrective behavior is altered in Alzheimer's Disease (AD). We found the pitch centering response in healthy elderly was similar when correcting pitch errors below and above the target (median) pitch. In contrast, patients with AD showed an asymmetry with a larger correction for the pitch errors below the target phonation than above the target phonation. These findings indicate that pitch centering is a robust compensation behavior in human speech. Our findings also explore the potential impacts on pitch centering from neurodegenerative processes impacting speech in AD.

摘要

过去的研究探讨了共振峰居中现象,即在一段话语的持续时间内,向假定目标元音的共振峰收敛的一种纠正行为。在本研究中,我们确定了健康老年对照组中存在类似的音高居中现象,并研究了这种纠正行为在阿尔茨海默病(AD)中是如何改变的。我们发现,健康老年人在纠正目标(中位)音高以下和以上的音高错误时,音高居中反应相似。相比之下,AD患者表现出不对称性,对目标发声以下的音高错误的纠正比对目标发声以上的音高错误的纠正更大。这些发现表明,音高居中是人类言语中一种强大的补偿行为。我们的研究结果还探讨了影响AD患者言语的神经退行性过程对音高居中的潜在影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f845/11371567/f56f6c7ddf0a/fnhum-18-1424920-g0001.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验