Ndoumba Annick Mintya, Chendjou Kamela Aurélien, Wamba Colince, Azebaze Agueguia Franklin, Carolle Nsa'Amang Eyebe, Tagny Claude Tayou, Mbanya Dora
Faculty of Medicine and Biomedical Sciences University of Yaoundé I, Yaoundé, Cameroon.
Yaounde University Teaching Hospital, Yaoundé, Cameroon.
Adv Hematol. 2024 Aug 28;2024:6660891. doi: 10.1155/2024/6660891. eCollection 2024.
In Cameroon, screening and diagnosis of minor hemorrhagic syndromes remain difficult and few research studies have been done to assess the magnitude of future bleeding risk and the burden of these disorders on quality of life. Epistaxis and menorrhagia are the two leading causes of bleeding disorders in the world population.
The aim of this study was to investigate the biological abnormalities of hemostasis in patients with epistaxis and menorrhagia.
From January to December 2021, we conducted a cross-sectional study in six hospitals with a gynecology and ENT department. We selected patients who presented epistasis or menorrhagia through clinical file and made them pass an interview and biological exams. Venous blood collected on EDTA tube allowed us to measure full blood count, thin blood smear, and blood grouping. PT, APPT, and fibrinogen assay were measured from citrate platelet-poor plasma. This plasma stored at -20°C for a maximum of 3 months allowed us to measure vWF : Ag and vWF : CBA ELISA. The bleeding time was measured at the time of sampling.
In total, our study population consisted of 60 patients aged 01-45 years. Epistaxis (40%) and menorrhagia (29%) were the two main causes of bleeding complaints in our study, in addition to gingivorrhagia (15%) and prolonged bleeding after injury (03%). Almost 60% of the population had at least one abnormal hemostasis parameter. The main abnormalities found were low von Willebrand factor (30.19%), presence of macroplatelets (16.98%), prolonged bleeding time (15.09%), prolonged PT (15.09%), and low platelet count (¬07.55%).
In Cameroon, bleeding disorders manifested by epistaxis and menorrhagia are mainly caused by abnormalities of primary hemostasis.
在喀麦隆，轻度出血综合征的筛查和诊断仍然困难，并且几乎没有研究来评估未来出血风险的程度以及这些疾病对生活质量的负担。鼻出血和月经过多是全球人群出血性疾病的两个主要原因。
本研究的目的是调查鼻出血和月经过多患者止血的生物学异常情况。
2021年1月至12月，我们在六家设有妇科和耳鼻喉科的医院进行了一项横断面研究。我们通过临床档案选择出现鼻出血或月经过多的患者，并让他们接受访谈和生物学检查。采集于乙二胺四乙酸（EDTA）管中的静脉血用于测量全血细胞计数、薄血涂片和血型。从枸橼酸盐少血小板血浆中测量凝血酶原时间（PT）、活化部分凝血活酶时间（APPT）和纤维蛋白原测定。储存在-20°C最多3个月的这种血浆用于测量血管性血友病因子抗原（vWF : Ag）和血管性血友病因子胶原结合活性（vWF : CBA）酶联免疫吸附测定（ELISA）。在采样时测量出血时间。
我们的研究人群共有60名年龄在1至45岁的患者。鼻出血（40%）和月经过多（29%）是我们研究中出血主诉的两个主要原因，此外还有牙龈出血（15%）和受伤后出血时间延长（3%）。近60%的人群至少有一项止血参数异常。发现的主要异常包括血管性血友病因子水平低（30.19%）、存在大血小板（16.98%）、出血时间延长（15.09%）、凝血酶原时间延长（15.09%）和血小板计数低（7.55%）。
在喀麦隆，以鼻出血和月经过多表现的出血性疾病主要由初级止血异常引起。
