Trose D, Slowig P
Pharmazie. 1985 Feb;40(2):124-6.
Aimed at the centralized manufacture of physostigmin salicylate injection solutions, the efficacy of different stabilizators has been studied under conditions of the thermic load. As for physostigmin sodium pyrosulphite is no antioxidant but a discolouration-protective agent. A decrease of the physostigmin content is not avoided. During the tests ascorbic acid proved to be the most efficient stabilizator, because its application resulted in the most favourable rates of storage stability and usability and at the same time in a pH stabilization to the optimum range of 3 necessary for the physostigmin keeping quality. An additionally stabilizing effect is obtained by a 5 min carbon dioxide gasing of the solutions. Moreover, ascorbic acid is as viewed in physiological perspective the most harmless one. A servicable stabilizing procedure for generation of 0.1% physostigmin salicylate injection solutions has been developed on this basis. These solutions had repeatedly and successfully been applied an antidote to intoxications with atropine syndrome, especially to intoxications with tricyclic anti-depressives and phenothiazines.
针对水杨酸毒扁豆碱注射液的集中生产，研究了不同稳定剂在热负荷条件下的功效。至于亚硫酸氢钠毒扁豆碱，它不是抗氧化剂，而是一种护色剂。毒扁豆碱含量的降低无法避免。在测试过程中，事实证明抗坏血酸是最有效的稳定剂，因为使用它能使储存稳定性和可用性达到最理想的水平，同时能将pH值稳定在毒扁豆碱保持质量所需的最佳范围3。通过对溶液进行5分钟的二氧化碳充气可获得额外的稳定效果。此外，从生理角度来看，抗坏血酸是最无害的。在此基础上，开发出了一种用于生产0.1%水杨酸毒扁豆碱注射液的可行稳定工艺。这些溶液已多次成功用作治疗阿托品综合征中毒，尤其是三环类抗抑郁药和吩噻嗪类中毒的解毒剂。
