Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China.
Department of Biochemistry & Molecular Biology, Dalian Medical University, Dalian, 116044, China.
Biomark Med. 2024;18(17-18):727-737. doi: 10.1080/17520363.2024.2389033. Epub 2024 Sep 5.
To identify novel metabolic biomarkers for patients with acute ischemic stroke (AIS). The metabolites in the sera of 63 patients with AIS aged 45∼77 years and 60 healthy individuals were analyzed by liquid chromatography (LC)-mass spectrometry (MS)/MS. The efficiency of significantly altered metabolites as biomarkers of AIS was evaluated by ROC curve analysis. Different metabolic profiles were revealed in AIS patients' sera compared with healthy persons. Twelve significantly altered metabolites had an area under the curve (AUC) value >0.80, demonstrating their potential as a biomarker of AIS. Among them, six metabolites are firstly reported to distinguish between AIS patients and healthy individuals. These 12 metabolites can be further researched as potential diagnostic biomarkers of AIS.
为了鉴定急性缺血性脑卒中（AIS）患者的新型代谢生物标志物。通过液相色谱（LC）-质谱（MS）/MS 分析了 63 名 45∼77 岁 AIS 患者和 60 名健康个体的血清中的代谢物。通过 ROC 曲线分析评估了差异代谢物作为 AIS 生物标志物的效率。与健康个体相比，AIS 患者的血清中显示出不同的代谢谱。12 种差异代谢物的曲线下面积（AUC）值>0.80，表明其有作为 AIS 生物标志物的潜力。其中，有 6 种代谢物是首次被报道可用于区分 AIS 患者和健康个体。这些 12 种代谢物可进一步作为 AIS 的潜在诊断生物标志物进行研究。
