Li Jiaqian, Dai Fangyu, Kou Xuelian, Wu Bin, Xu Jie, He Songbin
Department of Neurology, School of Medicine, Zhoushan Hospital, Zhejiang University, Zhoushan, 316000, Zhejiang Province, China.
Cell Mol Neurobiol. 2023 Mar;43(2):683-696. doi: 10.1007/s10571-022-01225-4. Epub 2022 May 13.
At present, the diagnosis of ischemic stroke mainly depends on neuroimaging technology, but it still has many limitations. Therefore, it is very important to find new biomarkers of ischemic stroke. Recently, β-actin has attracted extensive attention as a biomarker of a variety of cancers. Although several recent studies have been investigating its role in ischemic stroke and other cerebrovascular diseases, the understanding of this emerging biomarker in neurology is still limited. We examined human and preclinical studies to gain a comprehensive understanding of the literature on the subject. Most relevant literatures focus on preclinical research, and pay more attention to the role of β-actin in the process of cerebral ischemia, but some recent literatures reported that in human studies, serum β-actin increased significantly in the early stage of acute cerebral ischemia. This review will investigate the basic biology of β-actin, pay attention to the potential role of serum β-actin as an early diagnostic blood biomarker of ischemic stroke, and explore its potential mechanism in ischemic stroke and new strategies for stroke treatment in the future.
目前，缺血性中风的诊断主要依赖于神经影像学技术，但仍存在许多局限性。因此，寻找缺血性中风的新生物标志物非常重要。最近，β-肌动蛋白作为多种癌症的生物标志物引起了广泛关注。尽管最近有几项研究一直在探讨其在缺血性中风和其他脑血管疾病中的作用，但对这种新兴生物标志物在神经病学中的了解仍然有限。我们查阅了人体和临床前研究，以全面了解该主题的文献。大多数相关文献集中在临床前研究，更多关注β-肌动蛋白在脑缺血过程中的作用，但最近一些文献报道，在人体研究中，急性脑缺血早期血清β-肌动蛋白显著升高。本综述将研究β-肌动蛋白的基础生物学，关注血清β-肌动蛋白作为缺血性中风早期诊断血液生物标志物的潜在作用，并探讨其在缺血性中风中的潜在机制以及未来中风治疗的新策略。
