Fang Yueguang, Xiu Lanling, Xiao Dingwen, Zhang Danyang, Wang Miao, Dong Yuesheng, Ye Junwei
State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian, Liaoning, 116024, P. R. China.
School of Bioengineering, Dalian University of Technology, 2 Linggong Road, Dalian, 116024, P. R. China.
Adv Healthc Mater. 2024 Dec;13(31):e2402452. doi: 10.1002/adhm.202402452. Epub 2024 Sep 5.
The treatment of chronic diabetic wounds is a major challenge due to oxidative stress, persistent hyperglycemia, and susceptibility to bacterial infection. In this study, multifunctional sandwich-structured nanofiber dressings (SNDs) are prepared via electrospinning. The SNDs consisted of an outer layer of hydrophobic polylactic acid (PLA) fibers encapsulating MgB nanosheets (MgB NSs), a middle layer of PLA and polyvinylpyrrolidone (PVP) fibers encapsulating the MgB NSs and metformin hydrochloride complex (MgB-Met), and an inner layer of water-soluble PVP fibers encapsulating MgB-Met. Because of their special sandwich structure, SNDs have high photothermal conversion efficiency (24.13%) and photothermal cycle performance. SNDs also exhibit a photothermal effect, bacteria-targeting effect of MgB, electrostatic attraction ability of metformin hydrochloride (Met), and strong antibacterial activity against Escherichia coli (E. coli) and methicillin-resistant Staphylococcus aureus (MRSA). SNDs can eliminate intracellular reactive oxygen species (ROS) by regulating the hydrogen release from MgB. In addition, SNDs have good biocompatibility, can effectively inhibit the inflammatory factor Interleukin-6 (IL-6), and promote granulation tissue formation, collagen deposition, and diabetic wound healing. These findings offer a promising approach for clinical treatment of diabetic wounds.
由于氧化应激、持续性高血糖以及易受细菌感染，慢性糖尿病伤口的治疗是一项重大挑战。在本研究中，通过静电纺丝制备了多功能三明治结构纳米纤维敷料（SNDs）。SNDs由包裹MgB纳米片（MgB NSs）的疏水性聚乳酸（PLA）纤维外层、包裹MgB NSs和盐酸二甲双胍复合物（MgB-Met）的PLA和聚乙烯吡咯烷酮（PVP）纤维中间层以及包裹MgB-Met的水溶性PVP纤维内层组成。由于其特殊的三明治结构，SNDs具有高光热转换效率（24.13%）和光热循环性能。SNDs还表现出光热效应、MgB的细菌靶向效应、盐酸二甲双胍（Met）的静电吸引能力以及对大肠杆菌（E. coli）和耐甲氧西林金黄色葡萄球菌（MRSA）的强大抗菌活性。SNDs可以通过调节MgB释放氢气来消除细胞内活性氧（ROS）。此外，SNDs具有良好的生物相容性，能有效抑制炎症因子白细胞介素-6（IL-6），并促进肉芽组织形成、胶原蛋白沉积和糖尿病伤口愈合。这些发现为糖尿病伤口的临床治疗提供了一种有前景的方法。
