Department of Medical Biotechnology and Translational Medicine, University of Milano, 20129, Milan, Italy.
Department of Medicine, University of Udine, 33100, Udine, Italy.
Photochem Photobiol Sci. 2024 Sep;23(9):1749-1755. doi: 10.1007/s43630-024-00627-1. Epub 2024 Sep 5.
This mini-review reports a brief description of the first experiments conducted by Canti's group on the role of photodynamic therapy in generating immunity against cancer. It highlights for the first time the effective role of PDT in the induction of anti-tumor T lymphocytes and shows that this effect is tumor-specific. It has also been reported how this adoptive immunity can improve the efficacy of chemotherapy. These studies have helped to open an important new field of scientific research on the role of PDT-generated immunity and to stimulate today's important new pre-clinical approaches.
这篇迷你综述报告了 Canti 小组进行的首次关于光动力疗法在产生抗癌免疫方面作用的实验的简要描述。它首次强调了 PDT 在诱导抗肿瘤 T 淋巴细胞方面的有效作用，并表明这种作用是肿瘤特异性的。它还报告了这种获得性免疫如何提高化疗的疗效。这些研究有助于开辟 PDT 产生的免疫作用的重要新的科学研究领域，并激发当今重要的新的临床前方法。
