Laporte P, Viguier-Martinez M C, Zongo D, Le Floch O, Lipinski F
Reprod Nutr Dev (1980). 1985;25(2):355-66. doi: 10.1051/rnd:19850302.
Adult Wistar rats exposed to testicular radiocobalt irradiation (0.8 Gy) were alloted to four groups: sham control, protected control, unilaterally irradiated and bilaterally irradiated. The rats of each group were killed 30, 45, 60, 75 and 105 days after gamma-ray exposure and/or general anaesthesia. Tubular fluid (TF) production, estimated by ligature of the efferent ducts of both unilaterally and bilaterally irradiated testes, 24h prior to sacrifice, was transiently increased 30 and 45 days after irradiation (P less than 0.001); there was no increment in the interstitial fluid (or lymph) collected compared to sham and protected control testes. At 30 and 45 days, irradiated testis weight decreased significantly. From 60 to 105 days after gamma-ray exposure, TF gradually returned to control levels, while the testicular weight increased. The plasma FSH, LH, PRL and testosterone of the irradiated rats did not change significantly compared to the controls. Consequently, it is presumed that TF secretion was regulated locally by a germ cell-Sertoli cell interrelationship.
将成年Wistar大鼠暴露于睾丸放射性钴照射（0.8 Gy）下，分为四组：假手术对照组、保护对照组、单侧照射组和双侧照射组。每组大鼠在γ射线照射和/或全身麻醉后30、45、60、75和105天处死。在处死前24小时，通过结扎单侧和双侧照射睾丸的输出小管来估计管状液（TF）的产生，照射后30天和45天TF产生短暂增加（P小于0.001）；与假手术和保护对照睾丸相比，收集的间质液（或淋巴液）没有增加。在30天和45天时，照射侧睾丸重量显著下降。γ射线照射后60至105天，TF逐渐恢复到对照水平，而睾丸重量增加。与对照组相比，照射大鼠的血浆促卵泡激素（FSH）、促黄体生成素（LH）、催乳素（PRL）和睾酮没有显著变化。因此，推测TF分泌受生殖细胞-支持细胞相互关系的局部调节。
