Florén C H, Gustafson A
Scand J Clin Lab Invest. 1985 Apr;45(2):103-8. doi: 10.3109/00365518509160981.
Apolipoproteins A-I, A-II and E were determined in the plasma of nine patients (five females, four males) with cholestatic liver disease (eight patients with primary biliary cirrhosis and one patient with sclerosing cholangitis). Plasma concentrations were measured by electroimmunoassay in the fasting state, postprandially after ingestion of either 100 g fat as whipping cream or a light mixed meal with or without addition of wheat fibre. Concentrations of apolipoproteins A-I and A-II were low in patients with cholestatic liver disease and A-I levels correlated inversely with the severity of liver disease as measured by bilirubin levels (r = -0.66). No changes in plasma apolipoprotein A-I, A-II or E concentrations occurred postprandially. There was an inverse correlation between plasma concentrations of apolipoproteins A-I and E (p less than 0.05, r = -0.68). A close relation existed between the ratio of apolipoprotein E to apolipoprotein A-I and plasma bile salt concentration (r = 0.80, p less than 0.01) and serum bilirubin (r = 0.76, p less than 0.01). This implies that in cholestatic liver disease apolipoprotein E and A-I levels reflect the degree of cholestasis.
对9例胆汁淤积性肝病患者（5例女性，4例男性）（8例原发性胆汁性肝硬化患者和1例硬化性胆管炎患者）的血浆载脂蛋白A-I、A-II和E进行了测定。在空腹状态下、摄入100g搅打奶油形式的脂肪或清淡混合餐（添加或不添加麦麸）后餐后状态下，通过免疫电泳法测量血浆浓度。胆汁淤积性肝病患者的载脂蛋白A-I和A-II浓度较低，且载脂蛋白A-I水平与以胆红素水平衡量的肝病严重程度呈负相关（r = -0.66）。餐后血浆载脂蛋白A-I、A-II或E浓度无变化。血浆载脂蛋白A-I和E浓度之间呈负相关（p<0.05，r = -0.68）。载脂蛋白E与载脂蛋白A-I的比值与血浆胆汁盐浓度（r = 0.80，p<0.01）和血清胆红素（r = 0.76，p<0.01）之间存在密切关系。这表明在胆汁淤积性肝病中，载脂蛋白E和A-I水平反映了胆汁淤积的程度。
