Kesäniemi Y A, Miettinen T A
Scand J Gastroenterol. 1985 May;20(4):433-8. doi: 10.3109/00365528509089676.
Relationships between biliary bilirubin and lipid secretions were studied in patients with chronic cholestatic liver disease, mainly primary biliary cirrhosis. The bilirubin secretion rate in the patients was not significantly different from that in the controls. However, the bilirubin output per phospholipids, per bile acids, and per phospholipids plus bile acids was high, especially at low bile acid secretion rates. Thus, the bile of the patients with chronic cholestatic liver disease appears to be frequently 'supersaturated' with bilirubin. This metabolic abnormality may be associated with an increased risk of pigment stone formation in patients with cirrhosis.
在慢性胆汁淤积性肝病患者（主要是原发性胆汁性肝硬化患者）中，研究了胆汁胆红素与脂质分泌之间的关系。患者的胆红素分泌率与对照组无显著差异。然而，每磷脂、每胆汁酸以及每磷脂加胆汁酸的胆红素输出量较高，尤其是在胆汁酸分泌率较低时。因此，慢性胆汁淤积性肝病患者的胆汁似乎经常胆红素“过饱和”。这种代谢异常可能与肝硬化患者色素结石形成风险增加有关。
