用于干细胞分化的生物材料进展
Advancements in Biomaterials for Stem Cell Differentiation.
作者信息
Shao Mingchen, Rahmdel Mohamad, Shayan Sepideh Karkon, Hassannia Elham, Khedmatgozar Mohammad, Yousefi Khadije, Ali-Khiavi Payam, Hjazi Ahmed, Al-Aouadi Raed Fanoukh Aboqader, Sarvestani Paria Arjmandi, Fard Mohammad Reza Ghasemzadeh, Nourizadeh Mehrdad, Khiabani Saeid Shabestari, Suliman Muath, Nataj Paria Ganji, Hamzehzadeh Sina
机构信息
Department of Cardiovascular Surgery, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991, Moscow, Russian Federation.
Department of Radiation Oncology, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
出版信息
Stem Cell Rev Rep. 2025 Apr 21. doi: 10.1007/s12015-025-10879-8.
The field of regenerative medicine has witnessed significant advancements in recent years, particularly in the application of biomaterials to enhance stem cell differentiation. Biomaterials serve as scaffolds that can support cellular functions and influence the fate of stem cells through biochemical and physical cues. This paper reviews recent advancements in biomaterials designed for stem cell differentiation, focusing on their composition, properties, and applications in tissue engineering. We explore various types of biomaterials, including natural polymers, synthetic polymers, hydrogels, and nanomaterials, and discuss how they can be tailored to create microenvironments that promote specific differentiation pathways. Additionally, we highlight the challenges and future directions in this rapidly evolving field.
近年来，再生医学领域取得了重大进展，特别是在应用生物材料促进干细胞分化方面。生物材料作为支架，可以支持细胞功能，并通过生化和物理信号影响干细胞的命运。本文综述了为干细胞分化而设计的生物材料的最新进展，重点介绍了它们的组成、特性及其在组织工程中的应用。我们探讨了各种类型的生物材料，包括天然聚合物、合成聚合物、水凝胶和纳米材料，并讨论了如何对它们进行定制以创建促进特定分化途径的微环境。此外，我们还强调了这个快速发展领域中的挑战和未来方向。
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