用于关节软骨再生的创新水凝胶解决方案:全面综述。
Innovative hydrogel solutions for articular cartilage regeneration: a comprehensive review.
作者信息
Kang Yue, Guan Yujing, Li Shenglong
机构信息
Department of Breast Surgery, Cancer Hospital of Dalian University of Technology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute.
Institute of Cancer Medicine, Faculty of Medicine, Dalian University of Technology, Ganjingzi, Dalian, Liaoning Province, People's Republic of China.
出版信息
Int J Surg. 2024 Dec 1;110(12):7984-8001. doi: 10.1097/JS9.0000000000002076.
Articular cartilage damage is predominantly caused by trauma, osteoarthritis (OA), and other pathological conditions. The limited intrinsic capacity of cartilage tissue to self-repair necessitates timely intervention following acute injuries to prevent accelerated degeneration, leading to the development of planar arthritis or even osteoarthritis. Unfortunately, current therapies for articular cartilage damage are inadequate in effectively replacing or regenerating compromised cartilage due to the absence of suitable tissue-engineered artificial matrices. However, there is promise in utilizing hydrogels, a category of biomaterials characterized by their elasticity, smooth surfaces, and high water content, for cartilage regeneration. Recent advancements in hydrogel engineering have focused on improving their bioactive and physicochemical properties, encompassing innovative composition designs, dynamic modulation, and intricate architectures. This review provides a comprehensive analysis of hydrogels for articular cartilage repair, focusing on their innovative design, clinical applications, and future research directions. By integrating insights from the latest research studies and clinical trials, the review offers a unique perspective on the translation of hydrogels for articular cartilage repair, underscoring their potential as promising therapeutic agents.
关节软骨损伤主要由创伤、骨关节炎(OA)和其他病理状况引起。软骨组织自身修复的内在能力有限,因此急性损伤后需要及时干预,以防止加速退变,导致创伤性关节炎甚至骨关节炎的发展。不幸的是,由于缺乏合适的组织工程人工基质,目前用于关节软骨损伤的治疗方法在有效替代或再生受损软骨方面并不充分。然而,利用水凝胶(一类具有弹性、表面光滑且含水量高的生物材料)进行软骨再生具有前景。水凝胶工程的最新进展集中在改善其生物活性和物理化学性质,包括创新的成分设计、动态调控和复杂的结构。本综述对用于关节软骨修复的水凝胶进行了全面分析,重点关注其创新设计、临床应用和未来研究方向。通过整合最新研究和临床试验的见解,本综述为水凝胶在关节软骨修复中的转化提供了独特视角,强调了它们作为有前景的治疗剂的潜力。