Ralph Julia E, Lauck Bradley J, Colson Charles B, Ebangwese Santita, O'Neill Conor N, Anastasio Albert T, Adams Samuel B
Duke University School of Medicine, Durham, NC 27710, USA.
University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Gels. 2025 Apr 24;11(5):316. doi: 10.3390/gels11050316.
As tissue engineering and regenerative medicine (TERM) continues to revolutionize medicine and surgery, there is also growing interest in applying these advancements to foot and ankle surgery. The purpose of this article is to provide a comprehensive review of the types of gel scaffolds and templates, their applications in foot and ankle surgery, the challenges with current utilization, and the future directions of TERM in foot and ankle surgery. With multiple compelling scaffold prospects across the numerous natural, synthetic, and hybrid polymers currently utilized in TERM, promising results have been described in the treatment of osteoarthritis (OA) and osteochondral lesions (OCLs). However, concerns with material biocompatibility, structural integrity, feasibility during surgery, and degradation still exist and limit the extent of utilization. As researchers continue to develop enhanced polymers and formulations that address current issues, there are many opportunities to increase applications across foot and ankle surgery.
随着组织工程与再生医学（TERM）不断给医学和外科手术带来变革，将这些进展应用于足踝外科手术的兴趣也与日俱增。本文旨在全面综述凝胶支架和模板的类型、它们在足踝外科手术中的应用、当前应用面临的挑战以及TERM在足踝外科手术中的未来发展方向。在TERM目前使用的众多天然、合成和混合聚合物中，有多种引人注目的支架前景，在骨关节炎（OA）和骨软骨损伤（OCLs）的治疗中已取得了令人鼓舞的结果。然而，材料生物相容性、结构完整性、手术可行性和降解方面的问题仍然存在，并限制了其应用范围。随着研究人员不断开发能解决当前问题的改良聚合物和配方，足踝外科手术的应用机会将会增多。
