Department of Anesthesiology, The Third Xiangya Hospital, Central South University, No.138, Tongzipo Road, Yuelu District, Changsha, Hunan, China.
Department of Anesthesiology, The Third Xiangya Hospital, Central South University, No.138, Tongzipo Road, Yuelu District, Changsha, Hunan, China.
J Affect Disord. 2024 Dec 15;367:589-597. doi: 10.1016/j.jad.2024.09.008. Epub 2024 Sep 3.
Depression is a major public health problem worldwide and is closely related with systemic inflammatory responses. Additionly, physical activity (PA) is thought to be associated with lower levels of depression and inflammatory markers. This study aimed to elucidate the complex interactions between PA, depression, and inflammatory markers. Based on the National Health and Nutrition Examination Survey (NHANES), various logistic regression were applied to analyze the pairwise correlations among the three. Restrictive cubic splines were constructed to explore the nonlinear relationship between PA and depression. Mediation models were used to identify the mediating role of inflammatory markers. The findings revealed a positive link between depression and inflammatory marker, whereas PA was inversely correlated with both inflammatory marker and depression. Particularly, we noticed the greatest reduction in the risk of depression when the level of PA was between 1200 and 1722 MET-min/week. Besides, we demonstrated that inflammatory markers mediate the potential effects of physical inactivity on depression, ranging from 1.72 % to 6.25 %. In conclusion, PA appear to protect against depression, in which inflammatory markers may play a mediating role. Moreover, we determined the optimal dosage of PA to minimize the likelihood of depression, thereby offering valuable guidance for managing depression.
抑郁症是全球范围内一个主要的公共卫生问题，与系统性炎症反应密切相关。此外，人们认为身体活动（PA）与较低水平的抑郁和炎症标志物有关。本研究旨在阐明 PA、抑郁和炎症标志物之间的复杂相互作用。基于国家健康和营养检查调查（NHANES），应用各种逻辑回归分析了这三个因素之间的两两相关性。构建限制性三次样条以探索 PA 和抑郁之间的非线性关系。使用中介模型来确定炎症标志物的中介作用。研究结果表明，抑郁和炎症标志物之间存在正相关，而 PA 与炎症标志物和抑郁呈负相关。特别是，当 PA 水平在 1200 到 1722MET-min/周之间时，抑郁的风险降低最大。此外，我们还证明了炎症标志物在身体活动不足对抑郁的潜在影响中起中介作用，范围从 1.72%到 6.25%。总之，PA 似乎可以预防抑郁，其中炎症标志物可能起中介作用。此外，我们确定了 PA 的最佳剂量，以最大程度地降低抑郁的可能性，从而为管理抑郁提供了有价值的指导。
