Qiu Kunyu, Liu Yilei, Zhang Yan, Gu Jie, Huang Yanyan
Shanghai Putuo District Changzheng Town Community Health Service Center, Shanghai, 200333, China.
Department of General Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China.
BMC Psychiatry. 2025 Jul 16;25(1):709. doi: 10.1186/s12888-025-07095-6.
Depression is a prevalent disorder with significant health impacts. Physical activity is known to protect against depression, but its effects may vary in populations with disrupted sleep patterns, such as weekend catch-up sleepers, which refers to participants who sleep longer on weekends than on weekdays. This study examines the dose-response relationship between physical activity and depression in this population.
Data from 1,906 participants in the National Health and Nutrition Examination Survey (2021-2023) were analyzed. Physical activity was measured in MET-minutes per week, and depression was assessed using the PHQ-9. Multivariate linear regression, restricted cubic spline, and two-part linear regression models were employed.
In the adjusted model, physical activity showed a negative trend with depression, though this association did not reach statistical significance in the fully adjusted model. Stratified analyses revealed stronger associations in women (OR = 0.86, 95% CI: 0.75, 0.99, P = 0.0329) and individuals aged 40-60 years (OR = 0.79, 95% CI: 0.65, 0.97, P = 0.0237). A threshold effect was observed, with physical activity below 2.48 MET-min/1000-wk showing a negative association with depression (OR = 0.69, 95% CI: 0.56, 0.85, P = 0.0006). Beyond this threshold, the relationship changed.
A nonlinear relationship between physical activity and depression was identified in weekend catch-up sleepers, with moderate activity levels (2.48 MET-min/1000-wk) offering the greatest mental health benefits, particularly in women and individuals aged 40-60 years.
Not applicable.
抑郁症是一种普遍存在的疾病，对健康有重大影响。已知体育活动可预防抑郁症，但其效果在睡眠模式紊乱的人群中可能有所不同，比如周末补觉者，即周末睡眠时间比工作日长的参与者。本研究探讨了该人群中体育活动与抑郁症之间的剂量反应关系。
分析了来自国家健康与营养检查调查（2021 - 2023年）的1906名参与者的数据。体育活动以每周代谢当量分钟数来衡量，抑郁症使用患者健康问卷-9（PHQ - 9）进行评估。采用多变量线性回归、受限立方样条回归和两部分线性回归模型。
在调整模型中，体育活动与抑郁症呈负相关趋势，但在完全调整模型中这种关联未达到统计学显著性。分层分析显示，在女性（比值比[OR] = 0.86，95%置信区间[CI]：0.75，0.99，P = 0.0329）和40 - 60岁个体（OR = 0.79，95% CI：0.65，0.97，P = 0.0237）中关联更强。观察到一种阈值效应，体育活动低于2.48代谢当量分钟/1000周与抑郁症呈负相关（OR = 0.69，95% CI：0.56，0.85，P = 0.0006）。超过此阈值，关系发生变化。
在周末补觉者中发现体育活动与抑郁症之间存在非线性关系，中等活动水平（2.48代谢当量分钟/1000周）对心理健康益处最大，尤其是在女性和40 - 60岁个体中。
不适用。
