Lab of Regenerative Medicine in Sports Science, School of Physical Education and Sports Science, South China Normal University, Guangzhou, China.
Lab of Regenerative Medicine in Sports Science, School of Physical Education and Sports Science, South China Normal University, Guangzhou, China.
Int J Biol Macromol. 2024 Nov;279(Pt 3):135321. doi: 10.1016/j.ijbiomac.2024.135321. Epub 2024 Sep 3.
The exploration of novel therapeutic avenues for skeletal muscle atrophy is imperative due to its significant health impact. Recent studies have spotlighted growth differentiation factor 11 (GDF11), a TGFβ superfamily member, for its rejuvenating role in reversing age-related tissue dysfunction. This review synthesizes current findings on GDF11, elucidating its distinct biological functions and the ongoing debates regarding its efficacy in muscle homeostasis. By addressing discrepancies in current research outcomes and its ambiguous role due to its homological identity to myostatin, a negative regulator of muscle mass, this review aims to clarify the role of GDF11 in muscle homeostasis and its potential as a therapeutic target for muscle atrophy. Through a thorough examination of GDF11's mechanisms and effects, this review provides insights that could pave the way for innovative treatments for muscle atrophy, emphasizing the need and strategies to boost endogenous GDF11 levels for therapeutic potential.
由于骨骼肌萎缩对健康的重大影响，探索新的治疗方法迫在眉睫。最近的研究强调了生长分化因子 11（GDF11）作为转化生长因子-β（TGFβ）超家族成员在逆转与年龄相关的组织功能障碍方面的恢复活力作用。本综述综合了目前关于 GDF11 的研究结果，阐明了其独特的生物学功能以及关于其在肌肉内稳态中的功效的持续争论。通过解决当前研究结果中的差异以及由于其与肌肉质量负调节剂肌生成抑制素（myostatin）的同源性而导致的其作用不明确的问题，本综述旨在阐明 GDF11 在肌肉内稳态中的作用及其作为肌肉萎缩治疗靶点的潜力。通过对 GDF11 的机制和作用进行深入研究，本综述提供了一些见解，为肌肉萎缩的创新治疗方法铺平了道路，强调了提高内源性 GDF11 水平以发挥治疗潜力的必要性和策略。
