International Collaborative Laboratory for Air Pollution Health Effects and Intervention, School of Public Health, Xinxiang Medical University, Xinxiang, 453003, China.
Gansu Key Laboratory of Biomonitoring and Bioremediation for Environmental Pollution, School of Life Sciences, Lanzhou University, Lanzhou, 730000, China.
Environ Res. 2024 Dec 1;262(Pt 2):119930. doi: 10.1016/j.envres.2024.119930. Epub 2024 Sep 3.
Air pollution is one of the major environmental threats contributing to the global burden of disease. Among diverse air pollutants, fine particulate matter (PM) poses a significant adverse health impact and causes multi-system damage. As a highly dynamic organelle, mitochondria are essential for cellular energy metabolism and vital for cellular homeostasis and body fitness. Moreover, mitochondria are vulnerable to external insults and common targets for PM-induced cellular damage. The resultant impairment of mitochondrial structure and function initiates the pathogenesis of diverse human diseases. This review mainly summarizes the in vivo and in vitro findings of PM-induced mitochondrial dysfunction and its implication in PM-induced health effects. Furthermore, recent advances toward the underlying mechanisms of PM and its components-induced mitochondrial dysfunction are also discussed, with an attempt to provide insights into the toxicity of PM and basic information for devising appropriate intervention strategies.
空气污染是导致全球疾病负担的主要环境威胁之一。在各种空气污染物中，细颗粒物 (PM) 对健康的不良影响显著，并导致多系统损伤。作为一种高度动态的细胞器，线粒体对于细胞能量代谢至关重要，对于细胞内稳态和身体健康也至关重要。此外，线粒体易受外界刺激的影响，也是 PM 诱导细胞损伤的常见靶点。线粒体结构和功能的损伤会引发多种人类疾病的发生。本综述主要总结了 PM 诱导的线粒体功能障碍的体内和体外研究结果及其在 PM 诱导的健康影响中的意义。此外，还讨论了 PM 及其成分诱导的线粒体功能障碍的潜在机制的最新进展，试图为 PM 的毒性和制定适当干预策略提供基础信息。
