Jackson Daija A, Turner Aaron P, Raskin Sarah A, Neto Lindsay O, Gromisch Elizabeth S
The Chicago School, Washington, DC; Department of Behavioral Health, Brooke Army Medical Center, San Antonio, TX.
Multiple Sclerosis Center of Excellence West, Veterans Affairs, Seattle, WA; Rehabilitative Care Service, VA Puget Sound Health Care System, Seattle, WA; Department of Rehabilitative Medicine, University of Washington, Seattle, WA.
Arch Phys Med Rehabil. 2025 Feb;106(2):223-229. doi: 10.1016/j.apmr.2024.08.018. Epub 2024 Sep 3.
To examine the association between subjective and objective prospective memory (PM) in people with multiple sclerosis (PwMS).
Secondary analysis of a cross-sectional cohort study.
Community-based comprehensive multiple sclerosis center.
PwMS (N=112) who completed a battery that included measures of PM, depression, and fatigue.
Not applicable.
Objective PM was measured with the performance-based Memory for Intentions Test (MIST), whereas subjective PM was assessed with the self-report Perceived Deficits Questionnaire-Prospective Memory (PDQ-PM).
PwMS had low scores on the PDDS (median=2) and HADS-D (median=5.29), with 26.8% scoring 1 standard deviation or lower (≤15th percentile) on the MIST. Objective PM was significantly associated with subjective PM in a multivariate model (β=-0.18, P=.036), which accounted for demographics, physical disability, retrospective memory, and depressive and fatigue severity. Physical disability, depression, and fatigue were also significant contributors to subjective PM. Time-based PM performance emerged as the specific component that was associated with subjective PM.
These findings suggest that among PwMS with relatively mild impairment and symptomatology, their objective PM performance was associated with their self-assessments, even when considering retrospective memory and factors that influence their cognitive perceptions. The results expand upon the subjective-objective cognition discrepancy literature in multiple sclerosis and highlights how the PDQ-PM could be used as a complementary measure to help identify difficulties with PM.
研究多发性硬化症患者（PwMS）主观和客观前瞻性记忆（PM）之间的关联。
横断面队列研究的二次分析。
基于社区的综合性多发性硬化症中心。
完成了包括PM、抑郁和疲劳测量的一组测试的PwMS（N = 112）。
不适用。
客观PM通过基于表现的意向记忆测试（MIST）进行测量，而主观PM通过自我报告的前瞻性记忆感知缺陷问卷（PDQ-PM）进行评估。
PwMS在PDDS（中位数 = 2）和HADS-D（中位数 = 5.29）上得分较低，26.8%的人在MIST上得分在1个标准差或更低（≤第15百分位数）。在多变量模型中，客观PM与主观PM显著相关（β = -0.18，P = 0.036），该模型考虑了人口统计学、身体残疾、回顾性记忆以及抑郁和疲劳严重程度。身体残疾、抑郁和疲劳也是主观PM的重要影响因素。基于时间的PM表现是与主观PM相关的特定组成部分。
这些发现表明，在具有相对轻度损伤和症状的PwMS中，即使考虑回顾性记忆和影响其认知感知的因素，他们的客观PM表现仍与自我评估相关。这些结果扩展了多发性硬化症中主观-客观认知差异的文献，并强调了PDQ-PM如何可以用作辅助措施来帮助识别PM方面的困难。
