Hamachi Tomoyuki, Yanai Nobuhiro
Department of Applied Chemistry, Graduate School of Engineering, 744 Moto-oka, Nishi-ku, Fukuoka 819-0395, Japan.
Department of Applied Chemistry, Graduate School of Engineering, 744 Moto-oka, Nishi-ku, Fukuoka 819-0395, Japan; CREST, JST, Honcho 4-1-8, Kawaguchi, Saitama 332-0012, Japan.
Prog Nucl Magn Reson Spectrosc. 2024 Aug-Oct;142-143:55-68. doi: 10.1016/j.pnmrs.2024.05.001. Epub 2024 May 16.
Dynamic nuclear polarization (DNP) is a method for achieving high levels of nuclear spin polarization by transferring spin polarization from electrons to nuclei by microwave irradiation, resulting in higher sensitivity in NMR/MRI. In particular, DNP using photoexcited triplet electron spins (triplet-DNP) can provide a hyperpolarized nuclear spin state at room temperature and in low magnetic field. In this review article, we highlight recent developments in materials and instrumentation for the application of triplet-DNP. First, a brief history and principles of triplet-DNP will be presented. Next, important advances in recent years will be outlined: new materials to hyperpolarize water and biomolecules; high-sensitivity solution NMR by dissolution triplet-DNP; and strategies for further improvement of the polarization. In view of these developments, future directions to widen the range of applications of triplet-DNP will be discussed.
动态核极化（DNP）是一种通过微波辐射将自旋极化从电子转移到原子核来实现高水平核自旋极化的方法，从而提高核磁共振成像（NMR/MRI）的灵敏度。特别是，利用光激发三重态电子自旋的DNP（三重态-DNP）能够在室温及低磁场下提供超极化核自旋态。在这篇综述文章中，我们重点介绍了用于三重态-DNP应用的材料和仪器的最新进展。首先，将介绍三重态-DNP的简要历史和原理。接下来，将概述近年来的重要进展：用于使水和生物分子超极化的新材料；通过溶解三重态-DNP实现的高灵敏度溶液核磁共振；以及进一步提高极化的策略。鉴于这些进展，将讨论拓宽三重态-DNP应用范围的未来方向。
