Nishimura Koki, Kouno Hironori, Kawashima Yusuke, Orihashi Kana, Fujiwara Saiya, Tateishi Kenichiro, Uesaka Tomohiro, Kimizuka Nobuo, Yanai Nobuhiro
Department of Chemistry and Biochemistry, Graduate School of Engineering, Center for Molecular Systems (CMS), Kyushu University, 744 Moto-oka, Nishi-ku, Fukuoka 819-0395, Japan.
Cluster for Pioneering Research, RIKEN, RIKEN Nishina Center for Accelerator-Based Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Chem Commun (Camb). 2020 Jul 2;56(53):7217-7232. doi: 10.1039/d0cc02258f.
Dynamic nuclear polarization with photo-excited triplet electrons (triplet-DNP) has the potential to enhance the sensitivity of nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) at a moderate temperature. While many efforts have been devoted to achieving a large nuclear polarization based on triplet-DNP, the application of triplet-DNP has been limited to nuclear physics experiments. The recent introduction of materials chemistry into the field of triplet-DNP has achieved air-stable and water-soluble polarizing agents as well as the hyperpolarization of nanomaterials with a large surface area such as nanoporous metal-organic frameworks (MOFs) and nanocrystal dispersion in water. This Feature Article overviews the recently-emerged materials chemistry of triplet-DNP that paves new paths towards unprecedented biological and medical applications.
光激发三重态电子的动态核极化（三重态-DNP）有潜力在中等温度下提高核磁共振（NMR）和磁共振成像（MRI）的灵敏度。尽管人们为基于三重态-DNP实现大的核极化付出了诸多努力，但三重态-DNP的应用一直局限于核物理实验。最近将材料化学引入三重态-DNP领域，已实现了空气稳定且水溶性的极化剂，以及诸如纳米多孔金属有机框架（MOF）和水中纳米晶体分散体等具有大表面积的纳米材料的超极化。这篇专题文章概述了最近出现的三重态-DNP材料化学，为前所未有的生物和医学应用开辟了新途径。
