Rozenberg I, Manchon P, Sabatier C, Hazard J, Lhoste F
Acta Endocrinol (Copenh). 1985 May;109(1):19-24. doi: 10.1530/acta.0.1090019.
Plasma catecholamines assayed by a double isotope radio enzymatic method were studied in the basal state and during a thyrotrophin-releasing hormone (TRH)-test in 7 acromegalics, divided into 2 groups: active and non-active acromegalics, according to clinical and biological criteria. Basal plasma norepinephrine levels were significantly increased in the active group 648 +/- 22 pg/ml (P less than 0.001) and were in the normal range in the non-active group 439 +/- 26 pg/ml. Basal plasma epinephrine values were not significantly different in the 2 groups 59 +/- 15 pg/ml vs 34 +/- 7 pg/ml. During a TRH-test, norepinephrine levels remained elevated (P less than 0.001) in the active group, and the difference between the 2 groups was enhanced during the test. On the other hand the 2 patients who responded to TRH demonstrated an increase of norepinephrine levels. Our results suggest that TRH may stimulate norepinephrine release in acromegalics with an active response to TRH.
采用双同位素放射酶法测定了7例肢端肥大症患者在基础状态及促甲状腺激素释放激素（TRH）试验期间的血浆儿茶酚胺水平。根据临床和生物学标准，将这些患者分为2组：活动期和非活动期肢端肥大症患者。活动期组基础血浆去甲肾上腺素水平显著升高，为648±22 pg/ml（P＜0.001），非活动期组在正常范围内，为439±26 pg/ml。两组基础血浆肾上腺素值无显著差异，分别为59±15 pg/ml和34±7 pg/ml。在TRH试验期间，活动期组去甲肾上腺素水平持续升高（P＜0.001），试验期间两组间差异增大。另一方面，对TRH有反应的2例患者去甲肾上腺素水平升高。我们的结果表明，TRH可能刺激对TRH有活跃反应的肢端肥大症患者释放去甲肾上腺素。
