Farkhondeh Tahereh, Roshanravan Babak, Samini Fariborz, Samarghandian Saeed
Geriatric Health Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Department of Orthopedics, School of Medicine, Shafa Yahyaeian Orthopedics Hospital, Iran University of Medical Sciences, Tehran, Iran.
Curr Pharm Biotechnol. 2025;26(6):827-835. doi: 10.2174/0113892010307571240817190846.
Organophosphorus insecticides, widely used in farming and agriculture, have been associated with various health issues. Curcumin, a natural antioxidant, has shown potential in mitigating the adverse effects induced by these insecticides.
This study aimed to evaluate the nephroprotective effects of Curcumin (CUR) against Chlorpyrifos (CPF)-induced renal damage.
Forty male Wistar albino rats were randomly assigned to five groups, each containing eight rats: control (0.5 mL of olive oil, the solvent for chlorpyrifos), CPF (10 mg/kg of chlorpyrifos), CPF + CUR 25 mg/kg/day, CPF + CUR 50 mg/kg/day, and CPF + CUR 100 mg/k/day. All groups were treated for 90 days. Finally, kidney tissue was assessed for oxidative stress, inflammatory markers, and histopathological changes.
A considerable elevation in urea and Creatinine (Cr) concentrations was observed in the CPF group compared to the control rats (p < 0.01). CUR decreased creatinine and urea levels in the CPF-exposed group compared to the non-CUR-treated animals (p < 0.05). Additionally, the concentrations of NO, MDA, IL-6, IL-1β, and TNFα were significantly increased in the kidneys of the CPF-induced rats compared to the controls (p < 0.001). However, CUR (100 mg/kg) administration significantly reduced the abovementioned parameters in rat kidneys (p < 0.01). CUR (100 mg/kg) also increased superoxide dismutase activity and glutathione concentration in the kidneys of CPF-exposed animals compared to non-CUR-treated rats (p < 0.05). Histopathological analysis revealed severe congestion in the kidney tissue after CPF exposure. However, coadministration of CUR restored the normal structure of the kidney in the experimental rats.
Our findings suggest that curcumin, a potent antioxidant, can help alleviate chlorpyrifos-induced nephrotoxicity.
有机磷杀虫剂广泛应用于农业生产，与多种健康问题相关。姜黄素作为一种天然抗氧化剂，已显示出减轻这些杀虫剂所致不良反应的潜力。
本研究旨在评估姜黄素（CUR）对毒死蜱（CPF）诱导的肾损伤的肾保护作用。
将40只雄性Wistar白化大鼠随机分为五组，每组8只：对照组（0.5 mL橄榄油，毒死蜱的溶剂）、CPF组（10 mg/kg毒死蜱）、CPF + CUR 25 mg/kg/天组、CPF + CUR 50 mg/kg/天组和CPF + CUR 100 mg/k/天组。所有组均治疗90天。最后，对肾组织进行氧化应激、炎症标志物和组织病理学变化评估。
与对照大鼠相比，CPF组尿素和肌酐（Cr）浓度显著升高（p < 0.01）。与未用CUR治疗的动物相比，CUR降低了CPF暴露组的肌酐和尿素水平（p < 0.05）。此外，与对照组相比，CPF诱导的大鼠肾脏中一氧化氮（NO）、丙二醛（MDA）、白细胞介素-6（IL-6）、白细胞介素-１β（IL-1β）和肿瘤坏死因子-α（TNFα）的浓度显著增加（p < 0.001）。然而，给予CUR（100 mg/kg）可显著降低大鼠肾脏中的上述参数（p < 0.01）。与未用CUR治疗的大鼠相比，给予CUR（100 mg/kg）还可增加CPF暴露动物肾脏中的超氧化物歧化酶活性和谷胱甘肽浓度（p < 0.05）。组织病理学分析显示，CPF暴露后肾组织严重充血。然而，同时给予CUR可使实验大鼠的肾脏结构恢复正常。
我们的研究结果表明，强效抗氧化剂姜黄素可帮助减轻毒死蜱诱导的肾毒性。
