Zhang Hangzhen, Bai Jiafan, Chen Xiangli, Wang Linyu, Peng Wenzhen, Zhao Yuancong, Weng Jie, Zhi Wei, Wang Jianxin, Zhang Kai, Zhang Xingdong
Key Laboratory of Advance Technologies of Materials, Ministry of Education, College of Medicine and School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
Department of Biochemistry and Molecular Biology, College of Basic and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Regen Biomater. 2024 Aug 24;11:rbae105. doi: 10.1093/rb/rbae105. eCollection 2024.
Antibiotic resistance poses a huge threat to public health, which has increased the difficulty and transmission of disease treatment, as well as the burden and cost of medical institutions. In response to the current problems and challenges in inflammation control and treatment of bacterial infected wounds, inspired by antibacterial mechanisms based on active elements such as N, S, Cu and tannic acid (TA), a highly efficient multifunctional carbon quantum dot platform was proposed in this study and constructed through their special assembly in a solvothermal reaction system for the treatment of infected wounds. By introducing active elements such as N, S and Cu, this carbon quantum dot platform is endowed with antibacterial properties, while also achieving good angiogenesis promoting performance through the use of ion Cu. Meanwhile, the good antioxidant activity of TA (one of the precursors used) enables this platform to have better immunomodulatory performance . The research results on the treatment of bacterial infection models indicate that the multifunctional carbon quantum dots obtained can accelerate the healing of infected wounds by inhibiting bacterial infection, regulating immunoreaction, accelerating collagen deposition and promoting angiogenesis. This multifunctional carbon quantum dot platform shows good clinical application prospects in treating bacterial infected wounds. Additionally, the fluorescence characteristics of such carbon dots can be expected to realize visual therapy in the future.
抗生素耐药性对公众健康构成巨大威胁，增加了疾病治疗的难度和传播，以及医疗机构的负担和成本。针对目前细菌感染伤口炎症控制和治疗中存在的问题与挑战，受基于氮、硫、铜和单宁酸（TA）等活性元素的抗菌机制启发，本研究提出了一种高效多功能碳量子点平台，并通过它们在溶剂热反应体系中的特殊组装构建而成，用于治疗感染伤口。通过引入氮、硫和铜等活性元素，该碳量子点平台具有抗菌性能，同时通过离子铜实现了良好的促血管生成性能。同时，TA（所用前体之一）的良好抗氧化活性使该平台具有更好的免疫调节性能。对细菌感染模型的治疗研究结果表明，所制备的多功能碳量子点可通过抑制细菌感染、调节免疫反应、加速胶原蛋白沉积和促进血管生成来加速感染伤口的愈合。这种多功能碳量子点平台在治疗细菌感染伤口方面显示出良好的临床应用前景。此外，此类碳点的荧光特性有望在未来实现可视化治疗。
