Chin Yu-Ting, Wu Ming-Hsien, Shih Hou-Yu, Tsai Chia-Wen, Pei Jen-Sheng, Ke Tao-Wei, Wang Yun-Chi, Hung Yi-Chih, Chen Jaw-Chyun, Bau DA-Tian, Chang Wen-Shin
Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
Cancer Diagn Progn. 2024 Sep 1;4(5):579-585. doi: 10.21873/cdp.10366. eCollection 2024 Sep-Oct.
BACKGROUND/AIM: The role of alcohol consumption and aldehyde dehydrogenase 2 (ALDH2) genotype in hepatocellular carcinoma (HCC) development remains uncertain.
We conducted genotyping of the ALDH2 rs671 single nucleotide polymorphism in 298 patients with HCC and 889 non-cancerous healthy controls. We assessed associations stratified by sex and alcohol consumption status.
Distribution of ALDH2 rs671 variant genotypes differed significantly between HCC patients and controls (p=0.0311). Logistic regression analyses indicated that compared to the wild-type GG genotype, the heterozygous variant AG genotype and homozygous variant AA genotype conferred 1.22- and 1.77-fold increases in HCC risk (p=0.1794 and 0.0150, respectively). Allelic frequency analysis showed that the A allele was associated with a 1.29-fold increased HCC risk (p=0.0123). Additionally, AA genotype carriers had significantly higher HCC risk than GG genotype carriers among males (p=0.0145) and non-alcohol drinkers (p<0.001).
HCC risk is influenced by ALDH2 genotype, with effects modified by sex and alcohol consumption. Particularly, individuals with the ALDH2 rs671 AA genotype should avoid alcohol consumption, especially males.
背景/目的：饮酒和乙醛脱氢酶2（ALDH2）基因型在肝细胞癌（HCC）发生中的作用仍不明确。
我们对298例HCC患者和889例非癌健康对照者进行了ALDH2 rs671单核苷酸多态性基因分型。我们评估了按性别和饮酒状况分层的关联。
HCC患者与对照者之间ALDH2 rs671变异基因型的分布存在显著差异（p = 0.0311）。逻辑回归分析表明，与野生型GG基因型相比，杂合变异AG基因型和纯合变异AA基因型使HCC风险分别增加1.22倍和1.77倍（p分别为0.1794和0.0150）。等位基因频率分析显示，A等位基因与HCC风险增加1.29倍相关（p = 0.0123）。此外，在男性（p = 0.0145）和非饮酒者中（p < 0.001），AA基因型携带者的HCC风险显著高于GG基因型携带者。
HCC风险受ALDH2基因型影响，其作用因性别和饮酒情况而改变。特别是，携带ALDH2 rs671 AA基因型的个体应避免饮酒，尤其是男性。
