Bahrami Mahshid, Karami Fatemeh, Hekmatnia Ali, Soltani Sepideh, Fadavi Pedram, Hekmatnia Farzaneh, Zarei Andrew Parviz, Nazari Hengameh
Department of Radiology, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Radiology, Shafa Imaging Center, Isfahan, Iran.
J Res Med Sci. 2024 Jul 12;29:37. doi: 10.4103/jrms.jrms_587_22. eCollection 2024.
The aim of this study was to determine whether mammographic and sonographic features of malignant breast lesions are correlated with tumor histologic grade, hormonal receptor, human epidermal growth factor receptor 2 (HER2), and Ki-67 status.
In this retrospective study, imaging and histopathological findings of 187 biopsy-proven breast cancer cases from November 2019 to February 2021 were reviewed. The Chi-square test was used to examine the potential correlation between mammographic and sonographic characteristics with histopathological features such as hormonal receptor, HER2 status, Ki-67 labeling index, and histological grade.
We observed that microlobulated margin as well as oval/round morphology in mammograms correlate with triple-negative intrinsic subtype ( = 0.006 and = 0.004). The presence of calcification in sonography was significantly higher in the luminal-B subtype ( = 0.002). Furthermore, ill-defined margins in mammography were significantly higher in amplified HER2 expression ( = 0.004) in the same manner as an oval/round shape in higher levels of Ki-67 ( = 0.030).
Mammography and sonography features may reflect the biological behavior of various subtypes of breast cancer and can detect more aggressive breast cancers that can mimic benign or less malignant appearing lesions. These findings may be an excellent predictor for some subtypes like triple-negative breast cancer. Studying the range of these imaging characteristics may help in better understanding the prognosis, choosing a treatment strategy, and predicting response to treatment.
本研究的目的是确定乳腺恶性病变的钼靶和超声特征是否与肿瘤组织学分级、激素受体、人表皮生长因子受体2（HER2）和Ki-67状态相关。
在这项回顾性研究中，回顾了2019年11月至2021年2月期间187例经活检证实的乳腺癌病例的影像学和组织病理学检查结果。采用卡方检验来检验钼靶和超声特征与组织病理学特征（如激素受体、HER2状态、Ki-67标记指数和组织学分级）之间的潜在相关性。
我们观察到钼靶检查中的微叶状边缘以及椭圆形/圆形形态与三阴性内在亚型相关（P = 0.006和P = 0.004）。超声检查中钙化的出现率在管腔B亚型中显著更高（P = 0.002）。此外，钼靶检查中边界不清在HER2表达扩增的病例中显著更高（P = 0.004），同样，在Ki-67水平较高时椭圆形/圆形形态的病例中也是如此（P = 0.030）。
钼靶和超声特征可能反映了乳腺癌各种亚型的生物学行为，并且能够检测出更多可模拟良性或恶性程度较低的病变的侵袭性乳腺癌。这些发现可能是某些亚型（如三阴性乳腺癌）的良好预测指标。研究这些影像学特征的范围可能有助于更好地理解预后、选择治疗策略以及预测治疗反应。
