Gao B, Zhang H, Zhang S-D, Cheng X-Y, Zheng S-M, Sun Y-H, Zhang D-W, Jiang Y, Tian J-W
1 Department of Radiology, The Second Affiliated Hospital, Harbin Medical University, Harbin, China.
Br J Radiol. 2014 Jul;87(1039):20130496. doi: 10.1259/bjr.20130496. Epub 2014 Apr 15.
Triple-negative breast cancer (TNBC) lacks effective treatment and has a poor prognosis. This study assessed mammographic findings and clinicopathological features of TNBC by comparing with non-TNBC in order to improve clinical diagnosis of TNBC.
A total of 426 patients with pathologically confirmed breast cancer were retrospectively assigned into two groups, TNBC (n = 54) and non-TNBC (n = 372), and then analysed.
TNBC frequently showed a high histological grade, presented with a mass (79.6%) and was less frequently associated with focal asymmetric density (11.1%), microcalcifications (5.6%) and distortion (3.7%) on mammography. TNBC mammographic masses were most frequently round/oval (58.1%) or lobular (30.2%) in shape and were less frequently irregular in shape (11.6%). Masses with circumscribed margins were the most frequent (37.2%), with microlobulated (25.6%) and obscured (16.3%) margins being commonly observed, but masses with spiculated margins were rare (9.3%).
TNBC could have distinct mammographic and clinicopathological features compared with non-TNBC, and thus mammography may be useful in the diagnosis of TNBC.
This study demonstrated distinct mammographic and clinicopathological features to help in diagnosis of Chinese patients with TNBC.
三阴性乳腺癌（TNBC）缺乏有效的治疗方法，预后较差。本研究通过与非TNBC进行比较，评估TNBC的乳腺钼靶检查结果及临床病理特征，以提高TNBC的临床诊断水平。
回顾性分析426例经病理确诊的乳腺癌患者，将其分为TNBC组（n = 54）和非TNBC组（n = 372），并进行分析。
TNBC常表现为高组织学分级，以肿块形式出现（79.6%），乳腺钼靶检查中较少出现局灶性不对称致密影（11.1%）、微钙化（5.6%）和结构扭曲（3.7%）。TNBC乳腺钼靶肿块最常见的形状为圆形/椭圆形（58.1%）或分叶状（30.2%），形状不规则的较少见（11.6%）。边界清晰的肿块最为常见（37.2%），常见有微小分叶（25.6%）和模糊（16.3%）的边界，但边界有毛刺的肿块少见（9.3%）。
与非TNBC相比，TNBC可能具有独特的乳腺钼靶及临床病理特征，因此乳腺钼靶检查可能有助于TNBC的诊断。
本研究展示了独特的乳腺钼靶及临床病理特征，有助于诊断中国TNBC患者。
