针对铜绿假单胞菌脂多糖的小鼠单克隆抗体的特性分析。
Characterization of mouse monoclonal antibodies directed against Pseudomonas aeruginosa lipopolysaccharides.
作者信息
Sadoff J C, Wright D C, Futrovsky S, Sidberry H, Collins H, Kaufmann B
出版信息
Antibiot Chemother (1971). 1985;36:134-46. doi: 10.1159/000410478.
PMID:3923911
Abstract
Mouse monoclonal antibodies that react with O-side chain specific, O-side chain cross-reactive, and core P. aeruginosa lipopolysaccharide determinants have been isolated. The monoclonals directed at O-side chain determinants are generally opsonophagocytic with human neutrophils and human complement. They also protect mice from intraperitoneal and intravenous challenge and protect in the burned rat model of infection.
摘要
已分离出与铜绿假单胞菌O侧链特异性、O侧链交叉反应性及核心脂多糖决定簇发生反应的小鼠单克隆抗体。针对O侧链决定簇的单克隆抗体通常与人中性粒细胞及人补体具有调理吞噬作用。它们还能保护小鼠免受腹腔内和静脉内攻击，并在烧伤大鼠感染模型中发挥保护作用。
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