Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
Curr Opin Ophthalmol. 2013 Mar;24(2):125-9. doi: 10.1097/ICU.0b013e32835d9245.
Prior studies have not conclusively established a relationship between the choroid and glaucoma. The development of an enhanced imaging technique for spectral domain optical coherence tomography (SD-OCT) has allowed for measurements of choroidal thickness that are more accurate than previously possible. Therefore, the SD-OCT may be capable of documenting the changes in the choroid as they relate to glaucoma.
When applied to the SD-OCT, the technique of enhanced depth imaging allows for reproducible measurements of choroidal thickness. Nine reports have been published about choroidal thickness within the macula, as measured by OCT, in eyes with glaucoma. In six publications, there was no significant difference between the macular choroidal thicknesses of patients with glaucoma compared with those without glaucoma. Additional five studies have reported on peripapillary choroidal thickness in glaucoma patients. Although three of the studies determined that the peripapillary choroid is thinner in glaucoma patients, two others failed to establish this relationship.
The SD-OCT is capable of reproducibly measuring choroidal thickness in the peripapillary and macular areas. In those with glaucoma, choroidal thickness does not change within the macula. In a few subsets of glaucoma, the peripapillary choroid is thinner when compared with normals.
先前的研究并未明确脉络膜与青光眼之间的关系。频域光学相干断层扫描（SD-OCT）增强成像技术的发展使得脉络膜厚度的测量比以前更加准确。因此，SD-OCT 可能能够记录与青光眼相关的脉络膜变化。
当应用于 SD-OCT 时，增强深度成像技术可实现脉络膜厚度的可重复测量。有 9 篇关于青光眼患者黄斑区 OCT 测量的脉络膜厚度的报告。在 6 篇出版物中，青光眼患者的黄斑脉络膜厚度与无青光眼患者之间没有显著差异。另外 5 项研究报告了青光眼患者的视盘周围脉络膜厚度。尽管其中 3 项研究确定青光眼患者的视盘周围脉络膜较薄，但另外 2 项研究未能建立这种关系。
SD-OCT 能够在视盘周围和黄斑区域重复测量脉络膜厚度。在青光眼患者中，黄斑区的脉络膜厚度没有变化。在少数青光眼亚组中，与正常相比，视盘周围脉络膜较薄。
