四氢小檗碱对血小板聚集和血栓形成的抑制作用。
Inhibitory effect of tetrahydroberberine on platelet aggregation and thrombosis.
作者信息
Xuan B, Wang W, Li D X
机构信息
Department of Pharmacology, Nanjing Medical College, China.
出版信息
Zhongguo Yao Li Xue Bao. 1994 Mar;15(2):133-5.
Tetrahydroberberine (THB), an alkaloid extracted from Corydalis ambigua, inhibited the rabbit platelet aggregation triggered by arachidonic acid (AA), ADP, and collagen with IC50 of 0.86, 1.31, and 1.10 mmol.L-1, respectively. THB reduced the thromboxane B2 (TXB2) generation in rabbit platelet-rich plasma triggered by AA. THB 30 mg.kg-1.d-1 ip for 3 or 5 d restrained the ADP-induced platelet aggregation in rats. THB 30 mg.kg-1.d-1 ip for 1, 3, or 5 d inhibited the AA-induced platelet aggregation in rats. THB 15-30 mg.kg-1 iv showed an inhibition of venous thrombosis in rats. The results show that THB is a potent inhibitor of platelet aggregation in vitro and in vivo and is a promising antithrombotic drug.
四氢巴马汀（THB）是从延胡索中提取的一种生物碱，它能抑制花生四烯酸（AA）、二磷酸腺苷（ADP）和胶原蛋白引发的兔血小板聚集，其半数抑制浓度（IC50）分别为0.86、1.31和1.10 mmol·L-1。THB可减少AA引发的富含兔血小板血浆中血栓素B2（TXB2）的生成。THB以30 mg·kg-1·d-1的剂量腹腔注射3天或5天可抑制大鼠体内ADP诱导的血小板聚集。THB以30 mg·kg-1·d-1的剂量腹腔注射1天、3天或5天可抑制大鼠体内AA诱导的血小板聚集。THB以15 - 30 mg·kg-1的剂量静脉注射可抑制大鼠静脉血栓形成。结果表明，THB在体外和体内均是一种有效的血小板聚集抑制剂，是一种有前景的抗血栓药物。
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