Yde Ohki Cristine Marie, Walter Natalie Monet, Rickli Michelle, Iseli Cedric, Werling Anna Maria, Döring Christian, Rubio Belén, Hoffmann Per, Herms Stefan, Walitza Susanne, Grünblatt Edna
Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Human Genomics Research Group, Department of Biomedicine, University of Basel, 4031 Basel, Switzerland; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, 53105 Bonn, Germany.
Stem Cell Res. 2024 Dec;81:103546. doi: 10.1016/j.scr.2024.103546. Epub 2024 Sep 1.
As a neurodevelopmental multifactorial disorder whose prevalence has been increasing worldwide, attention-deficit hyperactivity disorder (ADHD) is considered a public health concern. Methylphenidate (MPH) is the drug of choice for ADHD; however, not all patients respond fully to this treatment. Therefore, exploring the underlying molecular mechanisms involved in ADHD and potential novel therapeutic targets is crucial. Here, we generated induced pluripotent stem cells (iPSCs) from Peripheral Blood Mononuclear Cells (PBMCs) retrieved from four ADHD patients (two MPH responders and two non-responders) using Sendai virus. These lines might be helpful for the in vitro investigation of ADHD pathophysiology in a patient-specific manner.
注意力缺陷多动障碍（ADHD）作为一种神经发育多因素疾病，其患病率在全球范围内呈上升趋势，被视为一个公共卫生问题。哌甲酯（MPH）是治疗ADHD的首选药物；然而，并非所有患者对这种治疗都有充分反应。因此，探索ADHD潜在的分子机制和新的治疗靶点至关重要。在此，我们使用仙台病毒从四名ADHD患者（两名MPH反应者和两名无反应者）获取的外周血单核细胞（PBMC）中生成了诱导多能干细胞（iPSC）。这些细胞系可能有助于以患者特异性方式在体外研究ADHD的病理生理学。
