从四位小儿多动症患者中生成无整合诱导多能干细胞系。
Generation of integration-free induced pluripotent stem cell lines from four pediatric ADHD patients.
机构信息
Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Human Genomics Research Group, Department of Biomedicine, University of Basel, 4031 Basel, Switzerland; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, 53105 Bonn, Germany.
出版信息
Stem Cell Res. 2021 May;53:102268. doi: 10.1016/j.scr.2021.102268. Epub 2021 Feb 24.
Human induced pluripotent stem cell (iPSC) lines have been derived from four male patients with childhood attention-deficit hyperactivity disorder (ADHD). Children and adolescents between the ages 6 and 18 suffering from ADHD were recruited for this work. Isolated keratinocytes or peripheral blood mononuclear cells from the participants were reprogrammed into iPSCs using non-integrating Sendai virus to deliver the reprogramming factors Oct3/4, Sox2, Klf4 and c-Myc.
已从四名患有儿童注意缺陷多动障碍 (ADHD) 的男性患者中获得了人类诱导多能干细胞 (iPSC) 系。这项工作招募了年龄在 6 至 18 岁之间患有 ADHD 的儿童和青少年。使用非整合性仙台病毒将来自参与者的分离角质形成细胞或外周血单核细胞重编程为 iPSC，以递送重编程因子 Oct3/4、Sox2、Klf4 和 c-Myc。
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