Powell G E, Polkey C E, McMillan T
Br J Clin Psychol. 1985 May;24 ( Pt 2):109-24. doi: 10.1111/j.2044-8260.1985.tb01321.x.
Cognitive effects of temporal lobectomy for the relief of focal seizures were examined in 59 adult cases (29 left and 30 right). Verbal and non-verbal intelligence and memory were tested pre-operatively and four weeks post-operatively. Slight, non-significant differences between left and right cases pre-operatively were added to by slight, non-significant differences in change across the operation, to produce some significant post-operative differences--right cases being significantly higher on verbal IQ and lower on non-verbal IQ, for example. Variation in cognitive outcome was related to certain subject variables. Those who showed no deterioration or more improvement across the operation tended to be younger, less intellectually able pre-operatively, had an earlier first seizure and an earlier onset of regular seizures. The implications of these results for a model of the effects of temporal lobectomy are discussed.
对59例成人患者（29例左侧颞叶切除，30例右侧颞叶切除）进行了研究，以考察颞叶切除术缓解局灶性癫痫发作的认知效果。术前及术后四周对语言和非语言智力及记忆力进行了测试。术前左右两侧病例之间轻微的、无显著差异，加上手术前后变化中轻微的、无显著差异，导致术后出现了一些显著差异——例如，右侧病例的语言智商显著更高，而非语言智商更低。认知结果的变化与某些受试者变量有关。那些在手术前后没有恶化或改善更多的人往往更年轻，术前智力较低，首次癫痫发作更早，癫痫发作规律的起始时间更早。讨论了这些结果对颞叶切除术效果模型的意义。
