Qi Shi-Zhou, Qin Gao-Feng, Miao Shuang, Lv Wen-Yuan, Ren Si-Qi, Gong Kai-Kai, Zhang Yong-Qing, Du Jing
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China.
Medical Research Center, Binzhou Medical University Hospital, Yellow River Second Road 661, Binzhou, 256603, China.
Chem Biodivers. 2025 Jan;22(1):e202401514. doi: 10.1002/cbdv.202401514. Epub 2024 Oct 28.
The Yellow River Delta possesses lots of characteristic medicinal plants due to its high salinity and high alkaline environment and Limonium sinense is an iconic plant. However, there are very few studies on L. sinense and its chemical constituents have not been investigated in recent ten years. In the present study, the chemical constituents and bioactivities of L. sinense were fully studied for the first time. UPLC-MS/MS method combined with database comparison identified 109 compounds mainly including flavonoids, alkaloids and polyphenols. In addition, the potential bioactivities of L. sinense were considerated as anti-inflammatory, anti-oxidative, anti-tumor, hepatoprotective and hpyerglycemic activities based on these identified compounds and their related literature. Furthermore, four derivatives of 12-oxo-phytodienoic acid and butenolide including two new ones (1 and 2) were isolated from the whole plants of L. sinense. Their structures, including the absolute configurations, were determined by the analysis of comprehensive spectroscopic data. All isolates were evaluated for their anti-inflammatory activity. Compound 1 exhibited moderate anti-inflammatory activity with IC value of 37.5±1.2 μM on NO production level.
