Institute of Neuroscience, Autonomous University of Barcelona, Spain.
Vall d'Hebron Hospital in Barcelona and professor at the Autonomous University of Barcelona, Spain.
Brain Dev. 2024 Nov;46(10):368-372. doi: 10.1016/j.braindev.2024.08.006. Epub 2024 Sep 5.
Very preterm birth is an important risk factor for autism spectrum disorder (ASD). The aim of this study is the early detection of ASD risk, using a follow-up protocol, in children weighing less than 1500 g at birth or born before 32 weeks of gestation.
This is a prospective longitudinal study in which a total of 133 very premature babies were monitored to the age of 2 years with the M-CHAT autism screening test and, in the event of a positive result, the Autism Diagnostic Observation Schedule (ADOS-2).
53 cases (4 out of 10) screened positive, and the rest negative. Among the positives, the ADOS-2 was administered in 50 cases, of which 24 scored above the ASD cutoff point. The average age of detection was 25.39 months. The results suggest an estimated prevalence of ASD in the very premature population of 18.46 %.
The application of the follow-up protocol in the very premature population is effective for early detection of ASD.
极早产是自闭症谱系障碍（ASD）的一个重要危险因素。本研究的目的是通过随访方案，在出生体重小于 1500 克或妊娠 32 周前出生的儿童中，早期发现 ASD 风险。
这是一项前瞻性纵向研究，共监测了 133 名极早产儿至 2 岁，使用 M-CHAT 自闭症筛查测试，如果结果阳性，则使用自闭症诊断观察量表（ADOS-2）。
53 例（10 例中的 4 例）筛查阳性，其余阴性。在阳性病例中，50 例进行了 ADOS-2 检查，其中 24 例得分高于 ASD 截断值。平均检出年龄为 25.39 个月。结果表明，极早产儿 ASD 的估计患病率为 18.46%。
在极早产儿人群中应用随访方案可有效早期发现 ASD。
