Chen Yu, Liu Shuke, Zhang Xueshan, Zuo Changpeng
Department of Cardiology, Wuxi Xishan People's Hospital, Wuxi, 214000, China.
Department of Cardiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, China.
Mol Biotechnol. 2024 Sep 6. doi: 10.1007/s12033-024-01272-w.
Acute myocardial infarction (AMI) is a heart lesion, that endangers the life safety of patients. This study focused on exploring the clinical effect of miR-542-3p on AMI and no-reflow after percutaneous coronary intervention (PCI). Serum samples were collected from 100 AMI emergency inpatients. The expression of miR-542-3p was quantified by qPCR. The predictive role of miR-542-3p was disclosed by plotting ROC curve. In addition, AMI subjects were cataloged into a group of no-reflow and normal reflow group. The risk factors of no-reflow were estimated by logistic regression analysis. In the serum samples of AMI patients, the level of miR-542-3p showed a pattern of decreasing. MiR-542-3p expression represented a high sensitivity and specificity of the prediction of AMI. A decrease of miR-542-3p content was revealed in AMI patients without reflow after PCI. Logistic regression results reflected that miR-542-3p was an independent biomarker for no-reflow. The declined miR-542-3p expression was a predictive marker for AMI and no-reflow in AMI patients.
急性心肌梗死（AMI）是一种危及患者生命安全的心脏病变。本研究聚焦于探讨miR-542-3p对急性心肌梗死及经皮冠状动脉介入治疗（PCI）后无复流的临床影响。收集了100例急性心肌梗死急诊住院患者的血清样本。通过qPCR对miR-542-3p的表达进行定量。绘制ROC曲线揭示miR-542-3p的预测作用。此外，将急性心肌梗死患者分为无复流组和正常复流组。通过逻辑回归分析评估无复流的危险因素。在急性心肌梗死患者的血清样本中，miR-542-3p水平呈下降趋势。miR-542-3p表达对急性心肌梗死的预测具有较高的敏感性和特异性。PCI后无复流的急性心肌梗死患者中miR-542-3p含量降低。逻辑回归结果表明，miR-542-3p是无复流的独立生物标志物。miR-542-3p表达下降是急性心肌梗死患者急性心肌梗死及无复流的预测标志物。
